بررسی ارتباط سطح سرمی ناتریورتیک مغزی و اینترلوکین 6 با کیفیت زندگی در بیماران مزمن انسدادی ریوی

قبادی مراللو, حسن and اصلانی, محمدرضا and حسینیان, عدالت and فرزانه, اسماعیل (1396) بررسی ارتباط سطح سرمی ناتریورتیک مغزی و اینترلوکین 6 با کیفیت زندگی در بیماران مزمن انسدادی ریوی. در: ERS International Congress 2017, Sep 9-13 , 2017, Milan- Itlay.


Official URL: http://erj.ersjournals.com/content/50/suppl_61/PA1...


The Correlation of Serum Brain Natriuretic Peptide and Interleukin-6 with Quality of Life using COPD assessment test

English Abstract

Background: Serum pro-brain natriuretic peptide (BNP) and interleukin (IL)-6 levels are increased with chronic obstructive pulmonary disease (COPD). The aim of the present study was to examine the levels of pro-BNP and IL-6 in stable COPD patients and the correlation of these markers with health-related quality of life using COPD assessment test (CAT). Method and Materials: Serum pro-BNP and IL-6 levels were measured in 82 patients with stable COPD. Serum pro-BNP levels, serum IL-6 levels, pulmonary function, and O2 saturation (Spo2) were compared according to GOLD stage and CAT score. Additionally, we tested association both pro-BNP and IL-6 with clinical parameters of patients. Results: Plasma IL-6 and pro-BNP levels increased with enhancing disease severity according to the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) classification (P=0.034, P=0.068; respectively). Also, results showed that plasma levels of pro-BNP and IL-6 were higher in patients with high CAT score (P=0.004, P=0.017; respectively). Additionally, there was positive significantly correlation between plasma pro-BNP and IL-6 levels (r= 0.332; P=0.002). Conclusion: The results demonstrated that with the increasing severity of the obstruction in patients with stable COPD, increased both IL-6 and pro-BNP. This increase in inflammatory markers is associated with reduced quality of life and severity of hypoxia. These results suggest that lowering of IL-6 and pro-BNP may be useful in the management of COPD patients.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده مسئول :حسن قبادی مراللو
نویسنده :محمدرضا اصلانی
نویسنده :عدالت حسینیان
نویسنده :اسماعیل فرزانه
Subjects:WF Respiratory System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:9700
Deposited By: Dr Mohammad Reza Aslani
Deposited On:02 Nov 1396 06:14
Last Modified:02 Nov 1396 06:14

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