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اثر حفاظت کلیوی عصاره متانولی گیاه بابونه گاوي(Tanacetum parthenium) بر آسیب کلیوی القا شده با تتراکلریدکربن در موش صحرایی

مأذنی, محمد ، محمودزاده, یاور ، چینی فروش, میرمهدی ، بنایی, شکوفه ، رضاقلی زاده, لطف اله ، محمدنیا, علیرضا (1397) اثر حفاظت کلیوی عصاره متانولی گیاه بابونه گاوي(Tanacetum parthenium) بر آسیب کلیوی القا شده با تتراکلریدکربن در موش صحرایی. Avicenna Journal of Phytomedicine ــ 8 (4). ص.ص.370-379. شاپا 2228-7930

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عنوان انگليسی

Renoprotective effects of the methanolic extract of Tanacetum parthenium against carbon tetrachloride-induced renal injury in rats

خلاصه انگلیسی

Objective: Studies have demonstrated that carbon tetrachloride (CCl4) increases the generation of reactive oxygen species (ROS) in many tissues including the kidney, heart, lung ,brain, and liver . The major aim of the present study was to evaluate the protective activity of Tanacetum parthenium extract (TPE) in renal tissues of CCl4-intoxicated rats. Materials and Methods: Animals were divided into seven groups of six rats. Group 1 was the control group that was not treated with CCl4. The rats in the other groups were intraperitoneally injected with CCl4 (1.5 ml/kg, 1:1 in olive oil) on day 14. Rats in the groups bTPE40, bTPE80, and bTPE120 were gavaged with 40, 80, and 120 mg/kg of TPE, respectively for 14 constitutive days on a daily basis, before CCl4 administration. Rats in groups aTPE80 and aTPE120 were gavaged with 80 and 120 mg/kg of TPE, respectively, 2, 6, 24 and 48 hr after receiving CCl4. Blood samples were collected at the end of the 16th day through an intracardiac puncture and then serums were separated. Results: CCl4 increased urea, creatinine, uric acid and creatinine: albumin (C/A) ratio level in serum and decreased total antioxidant and antioxidant enzymes (SOD and GPx) when compared to the control group (p<0.001). But administration of TPE to rats either before or after exposure to CCl4, attenuated these changes when compared with CCl4 control group (p<0.05 – p<0.001). Conclusion: TPE had potent nephroprotective effects against oxygen free radicals produced through CCl4 metabolism.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :محمد مأذنی
نویسنده :میرمهدی چینی فروش
نویسنده :شکوفه بنایی
نویسنده مسئول :لطف اله رضاقلی زاده
نویسنده :علیرضا محمدنیا
ضریب تاثیر و نمایه مجلات:Indexed in: ESCI, Pubmed/PMC, Chemical Abstracts, EMBASE, ISC, DOAJ, EBSCO, DRJI, Indexing biomedical journals published in Eastern Mediterranean Region, HINARI, Google Scholar, Index Copernicus, SID, Magiran, Iranmedex
کلیدواژه ها (انگلیسی):Tanacetum parthenium; Carbon tetrachloride; Antioxidant; Oxidative stress; Kidney
موضوعات :QU بیوشیمی
QV فارماکولوژی
WJ سیستم ادراری
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش بیوشیمی
کد شناسایی :9884
ارائه شده توسط : دکتر محمد مأذنی
ارائه شده در تاریخ :21 تیر 1397 11:13
آخرین تغییر :21 تیر 1397 11:13

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