title

اثر حفاظت کلیوی عصاره متانولی گیاه بابونه گاوي(Tanacetum parthenium) بر آسیب کلیوی القا شده با تتراکلریدکربن در موش صحرایی

مأذنی, محمد and محمودزاده, یاور and چینی فروش, میرمهدی and بنایی, شکوفه and رضاقلی زاده, لطف اله and محمدنیا, علیرضا (1397) اثر حفاظت کلیوی عصاره متانولی گیاه بابونه گاوي(Tanacetum parthenium) بر آسیب کلیوی القا شده با تتراکلریدکربن در موش صحرایی. Avicenna Journal of Phytomedicine ــ 8 (4). pp. 370-379. شاپا 2228-7930

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Title

Renoprotective effects of the methanolic extract of Tanacetum parthenium against carbon tetrachloride-induced renal injury in rats

English Abstract

Objective: Studies have demonstrated that carbon tetrachloride (CCl4) increases the generation of reactive oxygen species (ROS) in many tissues including the kidney, heart, lung ,brain, and liver . The major aim of the present study was to evaluate the protective activity of Tanacetum parthenium extract (TPE) in renal tissues of CCl4-intoxicated rats. Materials and Methods: Animals were divided into seven groups of six rats. Group 1 was the control group that was not treated with CCl4. The rats in the other groups were intraperitoneally injected with CCl4 (1.5 ml/kg, 1:1 in olive oil) on day 14. Rats in the groups bTPE40, bTPE80, and bTPE120 were gavaged with 40, 80, and 120 mg/kg of TPE, respectively for 14 constitutive days on a daily basis, before CCl4 administration. Rats in groups aTPE80 and aTPE120 were gavaged with 80 and 120 mg/kg of TPE, respectively, 2, 6, 24 and 48 hr after receiving CCl4. Blood samples were collected at the end of the 16th day through an intracardiac puncture and then serums were separated. Results: CCl4 increased urea, creatinine, uric acid and creatinine: albumin (C/A) ratio level in serum and decreased total antioxidant and antioxidant enzymes (SOD and GPx) when compared to the control group (p<0.001). But administration of TPE to rats either before or after exposure to CCl4, attenuated these changes when compared with CCl4 control group (p<0.05 – p<0.001). Conclusion: TPE had potent nephroprotective effects against oxygen free radicals produced through CCl4 metabolism.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمد مأذنی
نویسنده :میرمهدی چینی فروش
نویسنده :شکوفه بنایی
نویسنده مسئول :لطف اله رضاقلی زاده
نویسنده :علیرضا محمدنیا
Additional Information:Indexed in: ESCI, Pubmed/PMC, Chemical Abstracts, EMBASE, ISC, DOAJ, EBSCO, DRJI, Indexing biomedical journals published in Eastern Mediterranean Region, HINARI, Google Scholar, Index Copernicus, SID, Magiran, Iranmedex
کلیدواژه ها (انگلیسی):Tanacetum parthenium; Carbon tetrachloride; Antioxidant; Oxidative stress; Kidney
Subjects:QU Biochemistry
QV pharmacology
WJ Urogenital System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
ID Code:9884
Deposited By: Dr Mohammad Mazani
Deposited On:21 Apr 1397 11:13
Last Modified:21 Apr 1397 11:13

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