مقايسه اثربخشي 7٪، 5٪ هيپرتونيک سالين و 0.9٪ نرمال سالين در برونشيوليت حاد: يک مطالعه کنترل شده تصادفي

احدی, عادل and براک, منوچهر and امانی, فاطمه (1397) مقايسه اثربخشي 7٪، 5٪ هيپرتونيک سالين و 0.9٪ نرمال سالين در برونشيوليت حاد: يک مطالعه کنترل شده تصادفي. International Journal of Basic & Clinical Pharmacology ــ 7 (5). pp. 819-823. شاپا 2319-2003


Official URL: http://www.ijbcp.com/index.php/ijbcp/article/view/...


Comparing the efficacy of 7%, 5% hypertonic saline and 0.9% normal saline in acute bronchiolitis: a randomized controlled trial

English Abstract

Background: The study aimed to investigate the effect of nebulized 5% and 7% Hypertonic Saline (HS) versus Normal Saline (NS) in acute viral bronchiolitis. Methods: This is a prospective, randomized controlled trial study that has been done on 90 infants presenting with acute bronchiolitis. All infants divided randomly in three equal size and matched groups (n=30). Subjects received 4ml nebulized 5% and 7% HS along with 0.15mg/kg Adrenaline or 4 ml 0.9%NS every 6 hours from enrolment until hospital discharge. For all patients, clinical symptoms such as sputum, wheezing, retraction rate, heart rate, fever, crackle, irritability, week nutrition and breathing were recorded in baseline and length of wheezing, cough, and crackle, length of stay (LOS), fever and sputum based on days in the end of study. Collected data analyzed by statistical methods in SPSS.19. Results: At baseline, study groups were similar in demographic and clinical characteristics. The mean age of all patients was 5.5±3.6 months, and 59 (65.6%) were male. The length of cough and crackle, and the length of LOS in 5% and 7% HS groups was significantly lower than NS group. Conclusions: Among infants admitted to the hospital with viral bronchiolitis, treatment with nebulized 5% HS and 7% HS had significant effect on decreasing clinical symptoms length and LOS when compared with NS.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :عادل احدی
نویسنده مسئول :منوچهر براک
Additional Information:Indexed in: National Library of Medicine (NLM) Catalog, Index Copernicus, Index Medicus for South-East Asia Region (WHO),CrossRef, EBSCO A-to-Z, Ulrichsweb, Journal Index, Medical Journals Links, Google Scholar, J-Gate,Directory of Science
کلیدواژه ها (انگلیسی):Acute bronchiolitis, Hypertonic saline, Infants
Subjects:QV pharmacology > QV 754 Clinical Pharmacy
WF Respiratory System
WS Pediatrics
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
ID Code:9927
Deposited By: Dr Adel Ahadi
Deposited On:03 Feb 1397 15:03
Last Modified:03 Feb 1397 15:03

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