زمانی, بیژن ، باباپور, بهزاد ، نقوی-بهزاد, محمد ، تقی زاده-جاهد, مهناز ، علی خواه, حسین ، عباس نژاد, محسن (1393) اثر آتورواستاتین نسبت به دوز کم در پروتئین واکنش پذیر حساس C در سندرم حاد کرونری. Nigerian Medical Journal ــ 55 (6). ص.ص.490-494. شاپا 0300-1652
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آدرس اینترنتی رسمی : http://www.nigeriamedj.com/article.asp?issn=0300-1...
عنوان انگليسی
Effects of high versus low-dose atorvastatin on high sensitive C-reactive protein in acute coronary syndrome
خلاصه انگلیسی
Background: Cardiovascular disease is the leading cause of mortality. The previous findings which suggest the reduction in C-reactive protein (CRP) levels by statin encouraged us to conduct the present study in which we tested the effects of atorvastatin, on levels of hs-CRP in a prospective randomised clinical trial study on patients with acute coronary syndrome. Materials and Methods: Present prospective randomised clinical trial study conducted on 180 patients who had developed coronary artery disease and presented in emergency departments of Educational-Medical centers of Tabriz University of Medical Sciences. The patients were divided randomly into two groups and then two therapeutic protocols were given to them. One group medicated by high-dose atorvastatin (40 mg) and the other group received low-dose atorvastatin (20 mg). All variables were collected by questionnaires and were analyzed. Results: There were 180 patients consisted of 34 females and 56 males in low-dose atorvastatin group (L-DA group), and 30 females and 60 males in high-dose atorvastatin group (H-DA group) (P = 0.533). In this study atorvastatin in high doses decreased hs-CRP levels about 40% and in low doses it only caused decrease of 13.3%, and significant correlation was observed between two groups (Paired Sample T-test) (P = 0.001). Also atorvastatin in high doses decreased LDL levels about 23% and in low doses it only decreased 10%, and significant correlation was observed between two groups (Paired Sample T-test( (P = 0.001). Atorvastatin in high doses decreased HDL levels about 9% and in low doses it only decreased 6%, and again significant correlation was observed between two groups (P = 0.009). Conclusion: The present study confirms the novel observation that atorvastatin therapy results in a significant reduction in hs-CRP levels.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | بیژن زمانی |
نویسنده : | بهزاد باباپور |
نویسنده : | محمد نقوی-بهزاد |
نویسنده : | مهناز تقی زاده-جاهد |
نویسنده : | حسین علی خواه |
نویسنده مسئول : | محسن عباس نژاد |
ضریب تاثیر و نمایه مجلات: | Indexed in: Pubmed/PMC, Index Copernicus |
کلیدواژه ها (انگلیسی): | Atorvastatin, acute coronary syndrome, chest pain, hs-CRP |
موضوعات : | WG سیستم قلب و عروق |
بخش های دانشگاهی : | دانشكده پزشكي > گروه داخلی ، قلب ، عفونی |
کد شناسایی : | 10045 |
ارائه شده توسط : | دکتر فیروز امانی |
ارائه شده در تاریخ : | 29 اردبهشت 1397 12:20 |
آخرین تغییر : | 30 دی 1399 10:55 |
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