هاشمی, رضا ، مرشدی, محمد ، اصغری جعفرآبادی, محمد ، الطافی, داور ، حسینی اصل, سید سعید ، عارف حسینی, رفیع (1397) اثرات ضد التهابی ویتامین D3 بر بیماران مبتلا به مولتیپل اسکلروزیس. Neurology: Genetics ــ 4 (6). ص.ص.1-9. شاپا 2376-7839
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آدرس اینترنتی رسمی : http://ng.neurology.org
عنوان انگليسی
Anti-inflammatory effects of dietary vitamin D3 in patients with multiple sclerosis
خلاصه انگلیسی
Objective To assess the effects of dietary vitamin D3 on proinflammatory (interleukin-17A [IL-17A] and IL-6) and anti-inflammatory (IL-10) cytokines. Methods Our study was conducted on 75 participants who were divided into 3 groups: multiple sclerosis participants (MSPs, n = 25), first-degree relative participants (FDRPs, n = 25), and healthy participants (HPs, n = 25). All groups received 50,000 IU vitamin D3/wk for 8 weeks. Serum 25-(OH) vitamin D3 levels and messenger RNA (mRNA) expression levels of ILs were determined using electrochemiluminescence assay and real-time PCR, respectively. Results Vitamin D3 affected the levels of IL-17A, IL-10, and IL-6 among the 3 groups (p < 0.001 for all). Levels of IL-17A (MSPs: fold change [FC] = 5.9, p = 0.014; FDRPs: FC = 5.2, p = 0.006; HPs: FC = 4.2, p = 0.012) and IL-6 (MSPs: FC = 5.6, p = 0.003; FDRPs: FC = 5.5, p = 0.002; HPs: FC = 5.1, p < 0.001) were downregulated after vitamin D3 treatment. In addition, levels of IL-10 (MSPs: FC = 6.2, p = 0.005; FDRPs: FC = 4.6, p < 0.001; HPs: FC = 5.2, p < 0.001) were upregulated after 8 weeks. Conclusions Although supplementation with vitamin D3 reduced the mRNA expression levels of IL-17A and IL-6, it increased the mRNA expression level of IL-10 in all groups. However, these effects were more considerable in the MSP group than in the other groups. Of interest, in a deficiency state of serum vitamin D3, IL-17A expression had a positive feedback effect on the expression of IL-6. Conversely, in the sufficient state, IL-10 expression had a negative feedback effect on the expression of IL-17A and IL-6.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | رضا هاشمی |
نویسنده : | داور الطافی |
نویسنده : | سید سعید حسینی اصل |
نویسنده مسئول : | رفیع عارف حسینی |
ضریب تاثیر و نمایه مجلات: | Indexed in: ESCI, Pubmed/PMC, Scopus, EMBASE, Google Scholar, DOAJ |
موضوعات : | WL سیستم عصبی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش ژنتیک |
کد شناسایی : | 10904 |
ارائه شده توسط : | دکتر سید سعید حسینی اصل |
ارائه شده در تاریخ : | 30 آبان 1397 10:25 |
آخرین تغییر : | 30 آبان 1397 10:26 |
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