Benaissa, F ، محمودیان, مسعود ، محسنی راد, حامد (1388) بربرین اثر هیپوکسیک ایسکمیک را در مغز نوزاد موش کم میکند. Acta Physiologica Hungarica ــ 96 (2). ص.ص.213-220. شاپا 0231-424X
متن کامل
|
متنی
- نسخه چاپ شده
279kB |
آدرس اینترنتی رسمی : https://akademiai.com/doi/abs/10.1556/APhysiol.96....
عنوان انگليسی
Berberine reduces the hypoxic-ischemic insult in rat pup brain
خلاصه انگلیسی
Berberine, an isoquinoline alkaloid extracted from medicinal herbs, has been used as antipyretic, antidiarrheal, bactericide and anti-inflammatory agent. In this study, berberine effects on neuronal damage have been examined. The right carotid artery of seven-day-old rat pups was ligated (ischemic insult), then berberine solution (0.2, 0.5, 1 or 2 mg/kg) was injected intra-peritoneally, and 30 minutes later pups were passed through hypoxic condition with breathing in air containing 10% oxygen and 90% nitrogen(hypoxic insult). The day after that the brains of pups were enucleated for pathologic assessment. Pathologic review of the samples obtained from rats treated with different doses of berberine in comparison with samples from pups treated by normal saline showed that there was a significant reduction of brain injury and edema in the rats treated with berberine. Our study also demonstrates that berberine reduces brain ischemic-hypoxic injury dose-dependently. Therefore, beberine may be considered as useful anti-stroke agent.
نوع سند : | مقاله |
---|---|
زبان سند : | انگلیسی |
نویسنده اول : | F Benaissa |
نویسنده مسئول : | مسعود محمودیان |
نویسنده : | حامد محسنی راد |
ضریب تاثیر و نمایه مجلات: | IF:1.226 Indexing in: ISI, PubMed/Medline, Scopus |
کلیدواژه ها (انگلیسی): | berberine, hypoxic-ischemic insult, brain edema, rat pups, neuronal damage, brain injury, anti-stroke agent |
موضوعات : | QV فارماکولوژی > QV 754 داروسازی بالینی WL سیستم عصبی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه جراحی |
کد شناسایی : | 11147 |
ارائه شده توسط : | دکتر حامد محسنی راد |
ارائه شده در تاریخ : | 01 تیر 1398 08:19 |
آخرین تغییر : | 16 فروردین 1403 12:01 |
فقط پرسنل کتابخانه صفحه کنترل اسناد