ارزیابی اثرات لینالول بر روی پروفیل لیپیدی در موش های صحرایی آسیب دیده با تتراکلرید کربن

عنوان انگليسی

Evaluation of linalool effects on serum lipid profile on carbon tetrachloride damaged rats

خلاصه انگلیسی

Background and Objective: Linalool is a linear organic compound and monoterpene alcohol, which is found in several herbs such as coriander, Thymus, Hyssop and lavender. It seems to be effective in preventing and reducing damage caused by oxidants. Therefore, the s tudy is arranged out to evaluate the effects of linalool on lipid profiles in carbon tetrachloride (CCl4) induced oxidative damages in rats. Materials and methods: In this s tudy, 36 male Wis tar rats were divided into six groups (n=6), respectively, normal control, linalool control, injury control, pre-treatment with linalool, pretreatment with silymarin and pos t-treatment with linalool. For fourteen days, Groups I and III received dis tilled water, Groups II and IV received Linalool and finally Group V received silymarin. All the groups except groups I and III, were also intoxicated with 1.5 ml CCl4 (i.p, in a 1:1 dilution with olive oil) on the 14th day. Normal control and Linalool control groups received only olive oil. Group V was pos t-treatment group and received Linalool at 2, 6, 24 and 48h after CCl4 injection. At the end, blood serum samples were used for biochemical tes ts. Results: CCl4 significantly (p<0.05) increased triglyceride, choles terol, LDL levels and reduced HDL level when compared to the control group. The adminis tration of Linalool significantly (p<0.05) improved these alterations near to control rats. Conclusion: Linalool has protective effects agains t lipid profile alterations in carbon tetrachloride intoxicated rats.

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