تظاهرات اتوایمیون 47 بیمار مبتلا به نقص ایمنی متغیر شایع در دپارتمان الرژی و نقص ایمنی بیمارستان رسول اکرم تهران

عنوان انگليسی

AUTO IMMUNE MANIFESTATIONS OF 47 CVID PATIENTS REGISTERED AT THE ALLERGY AND IMMUNOLOGY DEPARTMENT OF RASOOL E AKRAM HOSPITAL IN TEHRAN

خلاصه انگلیسی

Allergy &clinical immunology Department of Rasool E Akram Hospital, Iran university of medical sciences, Tehran, Iran Common variable immune deficiency is a heterogeneous syndrome characterized by hypogammaglobulinemia , recurrent infections , auto immunity and auto-inflammation . More than 25 % of CVID patients have auto immune complications and among them, auto immune cytopenia is the most common. CVID patients with higher IgM level – higher 21 low B Cells – lower T reg levels – lower CD4/CD8 ratio and lower class switched memory B cells have higher prevalence of autoimmunity. Allergy and clinical immunology department of this hospital has registered 47 CVID patients. Mean age of onset of CVID symptoms was 11.2 years. Mean diagnosis age was 20.2 years with mean diagnostic delay of 9 years. Mean follow up time was 7 years (minimum 0.5 maximum 23 y). Autoimmunity was detected in 23 cases (49 %) and 12 cases (26 %) had more than one autoimmunity. Autoimmunity was the first symptom of CVID in 15 percent of cases. Autoimmune disorders should be considered in the follow up of CVID patients.

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