اثر رژیم غذایی پرچرب بر پاسخ دهی تراشه و التهاب مجاری هوایی در موش های صحرایی نر آسمی

عنوان انگليسی

Effect of high fat diet on trachea responsiveness and airway inflammation in male asthmatic rats

خلاصه انگلیسی

Introduction: Clinical and epidemiological studies show a close association between obesity and the risk of asthma development. The underlying cause–effect relationship between metabolism, innate and adaptive immunity, and inflammation remains to be elucidated. Methods: Forty male rats randomly divided to four groups, included: control group with normal diet, normal diet with sensitized with OA group, diet induced obesity group without sensitized with OA, and diet induced obesity group with sensitized with OA. All groups followed by assessment of inflammation and trachea responsiveness to methacholine. Results: Obesity index in animal model developed in diet induced obesity groups. This study showed increased tracheal responsiveness to methacholine in sensitized lean and obese rats compared with none sensitized obese and control groups. The maximum response to methacholine was also significantly greater in sensitized lean and obese rats compared to obese and non-obese controls. In addition total WBC number and percentage of differentiation cells significantly increased in sensitized lean and obese groups. Furthermore total WBC and number of differentiation cells increased in non sensitized obese rats compared with lean group. Conclusions: This obesity model demonstrates that high fat diet-induced obesity increased the lung inflammation in a model of asthma. This finding helps to understand why, particularly during childhood, obesity is a risk factor for the development of allergic asthma.

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