سعادت, سعیده ، محمدیان روشن, نما ، اصلانی, محمدرضا ، بسکابادی, محمد حسین (1399) روسواستاتین تولید سایتوکاین ها و التهاب ریه را در رتهای مدل آماتیک، هیپرلیپدمیک، و هیپرلیپدمیک توام با آسم را مهار می کند. Cytokine ــ 128 (154993). شاپا 1043-4666
متن کامل
![]() |
متنی
- نسخه چاپ شده
محدود به فقط پرسنل سامانه 8MB |
آدرس اینترنتی رسمی : https://www.sciencedirect.com/science/article/pii/...
عنوان انگليسی
Rosuvastatin suppresses cytokine production and lung inflammation in asthmatic, hyperlipidemic and asthmatic-hyperlipidemic rat models
خلاصه انگلیسی
Background: Given the role that T lymphocytes play on the pathogenesis of allergic asthma, drugs targeting Th2 and Th17 cells may be a hopeful therapeutic strategy. This study aimed to evaluate the effect of rosuvastatin treatment on cytokine production and lung inflammation in allergic asthma. Methods: The animals were assigned into control (C), asthmatic (A), hyperlipidemic (H), asthmatic-hyperlipidemic (AH), rosuvastatin (40 mg/kg/day intraperitoneally, for 3 weeks)-treated asthmatic (AR), rosuvastatintreated hyperlipidemic (HR) and rosuvastatin-treated asthmatic- yperlipidemic (AHR) groups (n = 6 in each group). The levels of IL-4, IFN-γ and IL-17, total and differential WBC counts in bronchoalveolar lavage fluid (BALF), Th1/Th2 balance, and pathological changes were evaluated. Results: The BALF level of IL-4 in A, H and AH groups, and IL-17A in A and AH groups were significantly higher than that in C group (p < 0.05 to p < 0.001). IFN-γ level and Th1/Th2 balance (IFN‑γ/IL-4 ratio) in A and AH groups were significantly decreased (p < 0.05 to p < 0.01). Inflammatory cells infiltration, muscle hypertrophy and emphysema were also observed in A and AH groups. The BALF levels of IL-4 in AR, HR and AHR groups, IFN-γ level in HR group, and IL-17A level in AR and AHR groups showed a significant improvement compared to that of A, H and AH groups (p < 0.05 to p < 0.001). Rosuvastatin treatment increased Th1/Th2 balance in all treated groups (p < 0.05 to p < 0.01), decreased total WBC counts, neutrophilia, eosinophilia and lung inflammation in AR and AHR groups, and improved muscle hypertrophy and emphysema in AHR group. Conclusions: Rosuvastatin treatment improved lung pathological changes by suppression of Th2 and Th17- mediated cytokines which was unrelated to its lipid-lowering activity. Therefore, rosuvastatin might be a candidate immunomodulatory drug for treatment of patients with allergic asthma
نوع سند : | مقاله |
---|---|
زبان سند : | انگلیسی |
نویسنده اول : | سعیده سعادت |
نویسنده : | نما محمدیان روشن |
نویسنده : | محمدرضا اصلانی |
نویسنده مسئول : | محمد حسین بسکابادی |
ضریب تاثیر و نمایه مجلات: | IF: 3.8 Indexed in: ISI, PubMed/Medline , Scopus |
کلیدواژه ها (انگلیسی): | Rosuvastatin , Asthma , Hyperlipidemia , Inflammation Th1-Th2 balance , Th17 cell |
موضوعات : | WF سیستم تنفسی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش فیزیولوژی |
کد شناسایی : | 12709 |
ارائه شده توسط : | دکتر محمد رضا اصلانی |
ارائه شده در تاریخ : | 17 اسفند 1398 08:21 |
آخرین تغییر : | 26 شهریور 1402 12:41 |
فقط پرسنل کتابخانه صفحه کنترل اسناد