سپهری, ساقی ، Perez Sanchez, Horacio ، فصیحی, افشین (1393) دی هیدروپیریدینهای نوع هانش و تتراهیدروپیریمیدینهای نوع بیجینلی: ریویوی فعالیتهای شیمی درمانی آنها. Journal of Pharmacy and Pharmaceutical Sciences ــ 18 (1). ص.ص.1-52. شاپا 1482-1826
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عنوان انگليسی
Hantzsch-Type Dihydropyridin es and Biginelli-Type Tetra- hydropyrimidines: A Review of their Chemotherapeutic Activities
خلاصه انگلیسی
Years after the first report on 1,4-dihydropyridines (1,4-DHPs) and 1,2,3,4-tetrahydropyrimidines (1,2,3,4-THPMs) appeared, they are revisited as plausible therapeutic agents. This is mainly due to the convenient methods that exist for their synthesis and the diverse pharmacologic properties that these scaffolds present. 1,4-Dihydropyridines and 1,2,3,4-tetrahydropyrimidines are usually regarded as analogous in several aspects. They are both prepared in multi-component reactions using very similar starting materials and synthesis protocols. This leads to common structural features between 1,4-DHPs and 1,2,3,4-THPMs, as well several related biological effects. For example, they share many pharmacological features such as analgesic, anti-tumor, antioxidant, anti-inflammatory, antitubercular, antibacterial, cardiovascular and adrenoceptor blocking activities. Numerous reviews have been devoted to the chemistry and cardiovascular effects of these compounds. However, the lack of a comprehensive literature overview on the chemotherapeutic ability of these scaffolds is behind the present attempt to provide a detailed survey of 1,4-DHPs and 1,2,3,4-THPMs and their structural features as chemotherapeutic agents.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | ساقی سپهری |
نویسنده : | Horacio Perez Sanchez |
نویسنده مسئول : | افشین فصیحی |
ضریب تاثیر و نمایه مجلات: | IF:1.497 Indexed in : ISI, PubMed/Medline, Scopus, Embase |
کلیدواژه ها (انگلیسی): | Dihydropyridines, anti-inflammatory,, Chemotherapeutic |
موضوعات : | QV فارماکولوژی > QV 744 شیمی دارویی |
بخش های دانشگاهی : | دانشکده داروسازی > بخش شیمی دارویی |
کد شناسایی : | 12822 |
ارائه شده توسط : | کاربر غیر معتبر |
ارائه شده در تاریخ : | 23 فروردین 1399 13:43 |
آخرین تغییر : | 11 اسفند 1401 12:48 |
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