نجفی, مسعود ، هوشنگی شایسته, محمدرضا ، مرتضایی, کیوان ، فرهود, باقر ، حقی امین جان, حامد (1399) نقش ملاتونین در قلبی ناشی از دوکسوروبیسین: یک بررسی سیستماتیک. Life sciences ــ 257 (15 Sep). ص. 118051. شاپا 0024-3205
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آدرس اینترنتی رسمی : https://www.sciencedirect.com/science/article/abs/...
عنوان انگليسی
The role of melatonin on doxorubicin-induced cardiotoxicity: A systematic review
خلاصه انگلیسی
Purpose: Doxorubicin, as an effective chemotherapeutic drug, is commonly used for combating various solid and hematological tumors. However, doxorubicin-induced cardiotoxicity is considered as a serious adverse effect, and it limits the clinical use of this chemotherapeutic drug. The use of melatonin can lead to a decrease in the cardiotoxic effect induced by doxorubicin. The aim of this review was to evaluate the potential role of melatonin in the prevention of doxorubicin-induced cardiotoxicity. Methods: This review was conducted by a full systematic search strategy based on PRISMA guidelines for the identification of relevant literature in the electronic databases of PubMed, Web of Science, Embase, and Scopus up to January 2019 using search terms in the titles and abstracts. 286 articles were screened in accordance with our inclusion and exclusion criteria. Finally, 28 articles were selected in this systematic review. Results: The findings demonstrated that doxorubicin-treated groups had increased mortality, decreased body weight and heart weight, and increased ascites compared to the control groups; the co-administration of melatonin revealed an opposite pattern compared to the doxorubicin-treated groups. Also, this chemotherapeutic agent can lead to biochemical and histopathological changes; as for most of the cases, these alterations were reversed near to normal levels (control groups) by melatonin co-administration. Melatonin exerts these protection effects through mechanisms of anti-oxidant, anti-apoptosis, anti-inflammatory, and mitochondrial function. Conclusion: The results of this systematic review indicated that co-administration of melatonin ameliorates the doxorubicin-induced cardiotoxicity.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | مسعود نجفی |
نویسنده : | محمدرضا هوشنگی شایسته |
نویسنده : | کیوان مرتضایی |
نویسنده مسئول : | باقر فرهود |
نویسنده مسئول : | حامد حقی امین جان |
ضریب تاثیر و نمایه مجلات: | IF: 3.647 Indexed in: ISI, Scopus, PubMed, Embase |
کلیدواژه ها (انگلیسی): | Cancer; Cardiotoxicity; Chemotherapy; Melatonin; Systemic review |
موضوعات : | QV فارماکولوژی > QV 600 سم شناسی QV فارماکولوژی |
بخش های دانشگاهی : | معاونت تحقیقات و فناوری > مرکز تحقیقاتی علوم دارویی |
کد شناسایی : | 13197 |
ارائه شده توسط : | دکتر حامد حقی امین جان |
ارائه شده در تاریخ : | 30 تیر 1399 09:28 |
آخرین تغییر : | 18 اسفند 1399 09:28 |
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