بررسی سطوح سرمی سرتوئین 1 در بیماران با کانسر ریه

عنوان انگليسی

Evaluation of serum levels of Sirtuin-1 in lung cancer patients

خلاصه انگلیسی

Background: Sirtuin-1 is a protein from the family of sirtuins that has been implicated in inflammaging and oxidative stress in cancer patients. The aim of this study was to investigate the serum level of Sirtuin-1 and its relation with quality of life in lung cancer. Methods: Sirtuin-1 levels were measured in 30 male with lung cancer and 50 healthy men. The two groups were matched for age. The difference between the serum levels of Sirtuin-1 between the two groups and its relationship with other clinical parameters were evaluated. Data were analyzed by independent T-test and Spearman correlation and P <0.05 was considered as significant. Results: Sirtuin-1 levels were significantly lower in the patient group in comparison with healthy group (P <0.001). There was also a significant relationship between serum level of Sirtuin-1 and quality of life according to Karnofsky scale (P = 0.001 r = 0.558), arterial oxygen saturation (P = 0.009 r = 0.470) and smoking history (P=0.003 r = - 0.330). Also, the serum levels of Sirtuin-1 were significantly lower in adenocarcinoma than that in squamous cell carcinoma or small cell lung cancer (p = 0.001). Conclusion: In this study, serum levels of sirtuin-1 were lower in patients with lung cancer. In addition, there was a positive correlation between serum levels of sirtuin-1 and patients' quality of life (according to Karnofsky scale), hypoxia and smoking history. Therefore, decreased serum sirtuin-1 levels in lung cancer reflect the cell aging process and correlate with poor quality of life.

Document Downloads