مفدرون به عنوان یک آمفتامین مصنوعی جدید باعث سقط جنین ، تغییرات مورفولوژیکی و اختلال عملکرد میتوکندری در جنین های موش می شود

عنوان انگليسی

Mephedrone as a new synthetic amphetamine induces abortion, morphological alterations and mitochondrial dysfunction in mouse embryos

خلاصه انگلیسی

We have studied the embryo-fetal toxicity of mephedrone in mice during organogenesis period on gestation day (GD) 6–15 in mice during organogenesis period intraperitoneally. Our observation showed that mephedrone induces abortion, reduction in the weight, length and diameter of the placenta and fetus. Also, histopathological and mitochondrial examinations showed pathological and mitochondrial abnormalities in placenta, liver and brain. Our data showed that mephedrone (20 mg/kg) adversely affects embryo-fetal/development in mouse fetus due to mitochondrial toxicity. Hope these results would be helpful for awareness of mephedrone addicts and their families and also medical society about mephedrone for its probable embryo-fetal toxicity.

Document Downloads