نادری پور, پرویز ، امانی, محمد ، عابدی, علی ، سخایی, نونا ، صادق زاده, فرشید ، سعادتی, حکیمه (1400) تغییرات در رفتار، عملکرد شناختی و سطح BDNF در موش های نر جوان به دنبال بلوک رسپتورهای GABA-A در دوره نوزادی. Brain Research Bulletin ــ 169 (2021). ص.ص.35-42. شاپا 0361-9230
متن کامل
![]() |
متنی
- نسخه چاپ شده
محدود به فقط پرسنل سامانه 2MB |
آدرس اینترنتی رسمی : https://www.sciencedirect.com/science/article/pii/...
عنوان انگليسی
Alterations in the behavior, cognitive function, and BDNF level in adult male rats following neonatal blockade of GABA-A receptors
خلاصه انگلیسی
Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the mature brain. At an early developmental period, it acts in an excitatory manner that influences many processes of proliferation, migration, and differentiation of the neurons. Previous evidence indicated that manipulation of the GABAergic system function by activation or blockade of its receptors during developmental periods leads to behavioral and cognitive abnormality in adulthood. Therefore, we examined the effects of neonatal blockade of GABA-A receptors by bicuculline on behavior, cognitive function, and hippocampal and prefrontal cortex (PFC) brain-derived neurotrophic factors level (BDNF) in adulthood. As a result, neonatal rats were treated with either bicuculline (75,150, and 300 μg/kg) or DMSO on postnatal days 7,9, and 11. These groups underwent the behavioral (open field, elevated plus maze, and hot plate) and learning and memory (passive avoidance learning and memory) tests in postnatal days (PNDs) 61−70. After the ending of the behavioral tests, the rats were sacrificed under deep anesthesia and the hippocampi and prefrontal cortex (PFC) of the brain were removed for assessing the BDNF mRNA expression. Our results indicated that neonatal administration of bicuculline at the highest dose increased passive avoidance memory and hippocampal BDNF level. Meanwhile, this drug at a low dose impaired this type of memory and increased PFC BDNF level. Besides, treatment with bicuculline during postnatal days increased anxiety and pain sensitivity in a dose-dependent manner. Taken together, these findings confirmed the notion that GABA-A receptors during the developmental period are important for programming neurobehavioral phenotypes in adult life.
نوع سند : | مقاله |
---|---|
زبان سند : | انگلیسی |
نویسنده اول : | پرویز نادری پور |
نویسنده : | محمد امانی |
نویسنده : | علی عابدی |
نویسنده : | نونا سخایی |
نویسنده : | فرشید صادق زاده |
نویسنده مسئول : | حکیمه سعادتی |
ضریب تاثیر و نمایه مجلات: | IF:3.8 Indexed in: ISI, PubMed/Medline, Scopus, Embase |
کلیدواژه ها (انگلیسی): | GABA- A receptors , Bicuculline , Memory , Anxiety , BDNF |
موضوعات : | WL سیستم عصبی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش فیزیولوژی |
کد شناسایی : | 13879 |
ارائه شده توسط : | دکتر حکیمه سعادتی |
ارائه شده در تاریخ : | 29 دی 1399 12:50 |
آخرین تغییر : | 01 مرداد 1402 09:16 |
فقط پرسنل کتابخانه صفحه کنترل اسناد