title

تیامین نشانه‌های سندروم متابولیک را در موشهای صحرایی با کاهش بیان ژن فاکتور هسته‌ای kB کبدی والقا فعالیت گلی‌اوکسیلاز-1 کاهش داد

مهدوی فرد, سیدسینا/ صفدر and دهقانی, راضیه and جدی, فرهاد and نجف زاده, نوروز (1399) تیامین نشانه‌های سندروم متابولیک را در موشهای صحرایی با کاهش بیان ژن فاکتور هسته‌ای kB کبدی والقا فعالیت گلی‌اوکسیلاز-1 کاهش داد. Iranian Journal of Basic Medical Sciences ــ 24 . pp. 293-299. شاپا 2008-3866

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Title

Thiamine reduced metabolic syndrome symptoms in rats via down-regulation of hepatic nuclear factor-kβ and induction activity of glyoxalase-I

English Abstract

Objective(s): Metabolic syndrome (MS) is a cause of death worldwide. The hepatic nuclear factor- NFkβ (NF-kβ) is the cardinal player of hepatic homeostasis, insulin sensitivity, and lipid metabolism. Thus, we investigated the effect of thiamine on hepatic gene expression of NF-kβ and its levels of activators in MS rats. Materials and Methods: Male Wistar rats were randomly divided into 4 equal groups (ten rats in each group): normal, MS, and two alike groups under thiamine treatment. MS was induced in rats with a high sucrose solution (40 % in drinking water) for 4 months. Treated groups of rats received 0.18 % of thiamine daily in drinking water. Hematoxylin-Eosin stains were employed to determine the histopathological changes of the liver. Metabolic profile, glycation products, oxidative stress, inflammatory markers, the activity of glyoxalase-I, as well as NF-kβ hepatic expression of all rat groups, were determined. Results: Acute hepatitis was not observed in the livers of the thiamine treated MS rats. Besides, the treatment showed an advantageous effect on glucose, lipid metabolism, and body weight via downregulation of hepatic NF-kβ and induction of glyoxalase system activity. Furthermore, the treatment decreased diverse glycation, oxidative stress, and inflammatory markers (P>0.001). Conclusion: Thiamine decreased body weight and improved metabolism and activity of glyoxalase-I in MS rats with anti-glycation, antioxidant, and anti-inflammatory activities. Further, the treatment had a hepato-protective effect via reduction of NF-kβ signaling

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :سیدسینا/ صفدر مهدوی فرد
نویسنده :راضیه دهقانی
نویسنده :فرهاد جدی
نویسنده :نوروز نجف زاده
Additional Information:IF=2.148 Indexed in: ISI, Scopus, PubMed/PMC, Embase
Uncontrolled Keywords:تیامین، فاکتور هسته‌ای KB،سندروم متابولیک، گلی‌اوکسیلاز-1، گلیکه
کلیدواژه ها (انگلیسی):Glycation , Glyoxalase-I , Metabolic syndrome , Nuclear factor- kβ , Thiamine
Subjects:QU Biochemistry
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:14054
Deposited By: Dr Sina Mahdavifard
Deposited On:24 Jan 1400 11:17
Last Modified:24 Jan 1400 11:17

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