حسینی نیا, سعید ، عاملی, سیداصلان ، اصلانی, محمدرضا ، پورفرضی, فرهاد ، قبادی مراللو, حسن (1400) سطح سرمی Sirtuin-1 در بیماران مبتلابه كانسر ريه وارتباط آن با وضعیت عملکرد کارنوفسکی. Acta Biomedica ــ 92 (2). e2021012. شاپا 0392-4203
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عنوان انگليسی
Serum Levels of Sirtuin-1 in Patients with Lung Cancer and its Association with Karnofsky Performance Status
خلاصه انگلیسی
Background: Lung cancer is a major cause of cancer-related deaths worldwide. There are conflicting results regarding the role of sirtuin-1 in cancer. This study aimed to evaluate the serum sirtuin-1 levels in patients with lung cancer and its relationship with the quality of life based on Karnofsky performance statue scale (KPS). Methods: Serum sirtuin-1 levels were measured in 30 male patients with lung cancer and 50 healthy men. The two groups were matched for age. The difference between the serum levels of sirtuin-1 between the two groups and its relationship with KPS and other clinical parameters were evaluated. Data were analyzed by independent t-test and Pearson correlation, and P < 0.05 was considered as significant. Results: Sirtuin-1 levels were significantly lower in the patients in comparison with healthy subjects (P < 0.001). There was also a significant relationship between the serum level of sirtuin-1 with KPS (P < 0.001, r = 0.634), arterial oxygen saturation (P < 0.01, r = 0.470), and smoking history (P < 0.01, r = -0.330). In addition, the serum sirtuin-1 levels were significantly lower in adenocarcinoma than that in squamous cell carcinoma or small cell lung cancer (p < 0.001 and P < 0.05, respectively). Conclusion: The serum levels of sirtuin-1 were lower in patients with lung cancer. In addition, there was a significant correlation between serum levels of sirtuin-1 and KPS, O2 saturation, and smoking history. Further serological and histological studies seem to be necessary due to the existence of conflicting reports regarding sirtuin-1.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | سعید حسینی نیا |
دانشجو : | سیداصلان عاملی |
ضریب تاثیر و نمایه مجلات: | Indexed in: PubMed/Medline, Scopus, Embase |
کلیدواژه ها (انگلیسی): | Karnofsky performance status; Lung cancer; Quality of life; Sirtuin-1 |
موضوعات : | WF سیستم تنفسی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه داخلی ، قلب ، عفونی معاونت تحقیقات و فناوری > مرکز تحقیقات بیماری های گوارشی |
کد شناسایی : | 14708 |
ارائه شده توسط : | دکتر سعید حسینی نیا |
ارائه شده در تاریخ : | 30 شهریور 1400 09:27 |
آخرین تغییر : | 03 مهر 1400 11:21 |
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