ارتباط سطح سرمی نسفاتین 1 با یافته های آنژیوگرافیک، اکوکاردیوگرافیک و بیوشیمیایی در بیماران با بیماری شریان کرونری

عنوان انگليسی

Serum Correlation of Nesfatin-1 with Angiographic, Echocardiographic, and Biochemical Findings in Patients with Coronary Artery Disease

خلاصه انگلیسی

Background and Aim: Nesfatin-1 is a peptide with metabolic effects that has been recently revealed to be closely related to a variety of chronic inflammatory diseases. The present study aimed at investigating the relation between nesfatin-1 levels and angiographic, biochemical, and echocardiographic findings, especially with the epicardial fat thickness (EFT) in patients with coronary artery disease. Methods: In a cross-sectional study, three groups were selected from 90 patients who were candidate for angiography, including 30 individuals as a control group with normal angiography but a history of chest pain, 30 patients with a diagnosis of stable angina pectoris (stable-AP), and 30 patients with a diagnosis of acute myocardial infarction (acute-MI). Demographic, biochemical, angiographic, and echocardiographic parameters were evaluated in all subjects. Results: Serum levels of nesfatin-1 in acute-MI and stable-AP groups were significantly reduced compared to the healthy subjects (P < 0.001 and P < 0.01, respectively), but there was no significant difference between acute-MI and stable-AP groups. In addition, the findings demonstrated that there was a negative relationship between nesfatin-1 and LDL-C, Gensini score, white blood cell, troponin T, EFT, and CK-MB, but there was a positive association with left ventricle ejection fraction (%). Conclusion: Decreased levels of nesfatin-1 in acute-MI and stable-AP groups as well as its association with several parameters such as EFT, CK-MB, and Gensini score, may indicate the potential role of nesfatin-1 in the process of atherosclerosis, which requires further studies.

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