رابطه ساختار اثر بیولوژیک در آزول های مهم به عنوان عوامل ضد قارچ (2016-2020)

عنوان انگليسی

Current Status and Structure Activity Relationship of Privileged Azoles as Antifungal Agents (2016–2020)

خلاصه انگلیسی

Fungal infections have greatly contributed to infectious-related deaths in the past century. This issue has become worse with the advent of immunity-impairing conditions such as HIV. The eukaryote na- ture of fungal pathogens makes them harder to eradicate than bacterial infections. Given the impor- tance of the problem, considerable efforts have been made to the synthesis and biological assessment of azole-based chemical scaffolds and their bioisosteres. The emergence of validated macromolecular tar- gets within different fungal species has inspired structure-based drug design strategies toward diverse azole-based agents. Despite advantageous features, the emergence of drug-resistant fungal species has restricted the applicability of current azoles as first-line antifungal agents. Consequently, it appears ad- visable to elucidate the structure activity relationships (SAR) and chemical biodiversity within antifungal azoles. This review is devoted to a brief look at clinically applied drugs, structure-based classification of azole antifungals and their SAR. The reviewed molecules belong to the antifungal structures that were reported throughout 2016–2020.

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