محافظت رزوراترول از اسپرماتوژنز موش های سوری در برابر سیمیت ناشی از بیسفنول A

عنوان انگليسی

Resveratrol protected mice spermatogenesis against bisphenol A-induced toxicity

خلاصه انگلیسی

BACKGROUND: Bisphenol A (BPA) is a xenoestrogen and is associated with male reproductive toxicity. Research has shown that BPA performs this process by altering the pattern of expression of genes involved in apoptosis as well as increasing oxidative stress. Previous studies have noted that the use of antioxidants can reduce the effects of BPA on the genital system. OBJECTIVE: We investigated the effect of resveratrol on reproductive toxicity induced by BPA in male mice. METHODS: Forty mice were randomly classified into five groups: Control; Bisphenol A; Bisphenol A + Resveratrol; Resveratrol and vehicle. Histological alterations, oxidative stress markers, and sperm parameters were examined. RESULTS: BPA caused an evident decrease in sperm motility, count, viability, and oxidative stress markers (p<0.05). Also, an increase in malondialdehyde, tissue damage, and abnormal sperm was observed in the BPA group (p<0.05) while the treatment with resveratrol significantly increased these disarrays (p<0.05). CONCLUSION: The results of this study showed that the administration of resveratrol prevents fertility damage caused by BPA.

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