تأثیر زردچوبه بر حفاظت میتوکندریایی و کاهش التهاب

عنوان انگليسی

Curcumin for protecting mitochondria and downregulating inflammation

خلاصه انگلیسی

The evidence has been shown that mitochondrial-derived reactive oxygen species (ROS) act as central regulators, checkpoints, and arbitrators in the inflammatory responses. It has been reported that mitochondrial ROS contributes to specific aspects of mitochondrial inflammation (mito-inflammation) in different inflammatory-related diseases such as diabetes, cardiovascular diseases, neurodegenerative disorders, cancer and pulmonary diseases. Mitochondrial-related oxidative stress stimulates oxidation of mitochondrial DNA (mtDNA), proteins, and lipids and leads to the release of the damage-associated molecular patterns (DAMPs) such as cardiolipin and mtDNA into cytosol. These DAMPs and oxidative stress can promote inflammatory responses by stimulating the generation of transcription factors, cytokines and related growth factors via oxidation of factors involved in inflammation such as nuclear factor κB (NF-κB). The activation of NF-κB as a key regulator of tissue inflammation increases the expression of eicosanoids, chemokines, cytokines, adhesion molecules and inducible nitric oxide synthase. Therefore, mitochondria are pivotal elements to trigger inflammation and stimulate innate immune signaling cascades in inflammatory-related diseases. Mitochondrial protection and mitochondrial ROS reduction can have an important effect on reducing inflammatory responses. Curcumin as an active compound found in turmeric has shown promising effects in reducing mitochondrial damage and mitochondrial-dependent oxidative stress. It seems that curcumin applies the mitochondrial protection effects and its subsequent antiinflammatory properties via different mechanisms such as ROS scavengers, enhancing of mitochondrial antioxidants, the activation of Nrf2, targeting of Sirtuins, p66Shc and uncoupling proteins, inhibition of cyclooxygenase-2, and monoamine oxidase enzymes. In this chapter we discuss the relationship between oxidative stress and inflammation, inflammation and mitochondria, and finally the importance of curcumin for protecting mitochondria and downregulating inflammation.

Document Downloads