استرس اکسیداتیو و ارتباط آن با از بین رفتن ST و ارتباط آن با نتایج بالینی در بیماران مبتلا به انفارکتوس میوکارد با صعود قطعه ST (STEMI) تحت مداخله اولیه عروق کرونر از راه پوست

عنوان انگليسی

Oxidative stress and its association with ST resolution and clinical outcome measures in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention

خلاصه انگلیسی

ObjectiveReperfusion of ischemic myocardium generates oxidative stress, which itself can mediate myocardial injury. So, in this study, we investigated the level of oxidative stress markers and its association with clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.ResultsAs indicated in the results, Post MI (Myocardial Infarction) heart failure was significantly higher in the group A (11% vs 4%, p=0.047). Complete STR (ST-segment resolution) was observed to be significantly higher in the group B (36% vs 17%, p=0.006). The SOD (Superoxide dismutase) and GPX (Glutathione peroxidase) levels were significantly higher in the group B compared to the other group (1547.51 +/- 328.29 vs. 1449.97 +/- 246.06, p=0.019 and 60.62 +/- 11.95 vs 57.41 +/- 10.14, p=0.042). The levels of GPX and SOD were shown to be directly related with complete STR and post PCI (Percutaneous coronary intervention)TIMI(Thrombolysis in Myocardial Infarction) flow 3 in the group A (p=0.002 and p<0.01, p=0.005 and p<0.02, respectively).

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