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مرگ و میر COVID-19 در بیماران مبتلا به نقص ایمنی و عوامل پیش بینی کننده آن: یک مرور نظام مند

سید علی نقی, سید احمد ، کریمی, امیر علی ، برزگری, علیرضا ، مژدگانلو, هنگامه ، واحدی, فرزین ، میرقادری, سیدپیمان ، شوبیری, پرنیان ، رمضانی, مریم ، یوسفی, پریسا ، میرزاپور, پگاه ، M. Tantuoyir, Marcarious ، مهرآیین, اسماعیل ، دادرس, امید ، Voltarelli, Fabricio (1401) مرگ و میر COVID-19 در بیماران مبتلا به نقص ایمنی و عوامل پیش بینی کننده آن: یک مرور نظام مند. European Journal of Medical Research ــ 27 (1). ص. 195. شاپا 2047-783X

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عنوان انگليسی

COVID-19 mortality in patients with immunodeficiency and its predictors: a systematic review

خلاصه انگلیسی

Introduction: Patients with immunodeficiency are usually more prone to worse outcomes of infectious diseases. However, there are some disagreements in the context of COVID-19, for example, in patients with human immunodeficiency virus (HIV). Herein, we aimed to systematically review the risk and predictors of COVID-19 mortality in people with primary or secondary immunodeficiency. Methods: PubMed, Scopus, Web of Science, and Science Direct were searched. We followed a two-step screening process to identify eligible results. We first reviewed the title and abstract of the records and the unqualified studies were removed. Then, their full texts were evaluated based on their coherence with the purpose and inclusion/exclusion criteria, and those eligible for qualitative synthesis were included. Results: Twenty-two articles were included, which investigated a total of 109,326 with primary or secondary immunodeficiencies. Three studies investigated the pediatric and infant population, while other studies were conducted on the adult population. Overall, studies on both primary and secondary immunodeficiency conflicted as some reported higher and some mentioned lower mortality rates in patients with immunodeficiency. Conclusions: Overall, there were two points of view in both types of immunodeficiencies. The first is the classical viewpoint that all immunodeficient patients are at a higher risk of infection leading to a higher mortality rate. The second types of studies found that immunodeficiency might play a less important or even an inverse role in mortality rates by lowering the severity of the inflammatory response. However, it is important to take note to comorbidities, such as DM, HTN, CAD, ESRD, history of lower respiratory infection, etc., and demographic factors, such as obesity and age>70 years, as they appear to influence the mortality rate, especially in patients with secondary immunodeficiency.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :سید احمد سید علی نقی
نویسنده :امیر علی کریمی
نویسنده :علیرضا برزگری
نویسنده :هنگامه مژدگانلو
نویسنده :فرزین واحدی
نویسنده :سیدپیمان میرقادری
نویسنده :پرنیان شوبیری
نویسنده :مریم رمضانی
نویسنده :پریسا یوسفی
نویسنده :پگاه میرزاپور
نویسنده :Marcarious M. Tantuoyir
نویسنده مسئول :اسماعیل مهرآیین
نویسنده :امید دادرس
نویسنده :Fabricio Voltarelli
ضریب تاثیر و نمایه مجلات:IF: 4.981 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):COVID-19, Immunocompromised, Immunodeficiency, Immunosuppression, Impaired immune response, SARS-CoV-2, Comorbidities
موضوعات :WC بیماریهای واگیر
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش مدیریت اطلاعات سلامت
کد شناسایی :16698
ارائه شده توسط : دکتر اسماعیل مهرآیین
ارائه شده در تاریخ :11 بهمن 1401 09:42
آخرین تغییر :11 بهمن 1401 09:42

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