کشف مشتقات بنزوتیازینون به عنوان عامل ضد جلبک: سنتز، فعالیت ضد جلبک، ضد میکروب و مطالعات داکینگ مولکولی

عنوان انگليسی

Discovery of Benzothiazinone derivatives as anti-algae agent: Synthesis, anti-algae, antimicrobial activity and molecular docking studies

خلاصه انگلیسی

Synthesis of compounds with new applications having biological properties and lower side effects is always demanded. This study aimed to introduce 1,4-Benzothiazinone as a new anti-algae products as well as antibacterial agent to reduce the destructive effects of algae such as causing problems in industrial equipment. Several benzothiazinone derivatives were synthesized quickly and environmentally friendly utilizing the reaction of 2-aminothiophenols and 2-bromoalkanoates, ball milling as the technique, and solvent-free conditions. Using the disc diffusion method, the anti-algae and antibacterial properties of all the produced compounds were examined. Except for compound C10, all compounds had a significant growth inhibition on Spirulina platnesis. Additionally, when compared to traditional antibiotic (amikacin), the compounds showed excellent activity against Gram-positive bacteria. The in silico analysis carried out to forecast the conformation of the compounds under examination suggested that these compounds might significantly bind to critical residues in the active site of dihydropteroate synthase (DHPS). The results of the in vitro and in silico experiments agreed.

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