اثرات دوز پائین نالوکسان در بروز تشنج در درمان مسمومیت با ترامادول

عنوان انگليسی

Seizurogenic Effects of Low-dose Naloxone in Tramadol Overdose

خلاصه انگلیسی

Objective: Tramadol is used in treatment of moderate to severe pain. Nowadays tramadol overdose is one of the common emergencies. Naloxone is an antagonist which is used as a first step of treatment in these patients. This study was designed to evaluate the seizurogenic effects of naloxone in tramadol overdose. Methods: 124 patients with the diagnosis of tramadol overdose were divided to receive low-doses of intravenous naloxone (0.8 mg, case group) or just supportive cares (control group). All patients in case and control groups were observed by a single emergency resident and fallowed for 1.5 hours to document the happening of seizures. Results: In the naloxone group, incidence of seizure was higher than in control group. The possibility of seizure occurrence was significantly higher in naloxone group than the control group (P < 0.05). Conclusion: Naloxone induced a seizurogenic effect in patients with tramadol overdose. This finding could be considered in the management of patients with tramadol overdose.

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