مطالعه اثر مهاری عصاره هومولوس لوپولوس (رازک) بر آسیب میوکارد قلب القا شده توسط تتراکرید کربن در موش های صحرایی

عنوان انگليسی

The protective effects of Humulus lupulus (hop) extract on carbon tetrachloride-induced myocardium injury in rats

خلاصه انگلیسی

Background and Aim: Cardiovascular diseases are the most common causes of death and disability in the world. The aim of this study was to investigate the protective effects of Humulus lupulus (hop) on myocardium injury induced by carbon tetrachloride (CCl4) in rats. Methods: In this study, 24 male Wistar rats (200 – 250 g) randomly were categorized into four groups (n=6). Groups 1 and 2 received physiologic serum for two weeks, while groups 3 and 4 received 100 and 200 mg/kg hop extract daily for two weeks, respectively. To induce heart damage, except for group 1, all other groups received a mixture of carbon tetrachloride and olive oil (1:1) at a dose of 1 ml/kg body weight on the 14th day. Forty-eight hours after the injection, the animals were anesthetized by intraperitoneal injection of ketamin and xylazin, then the samples were taken. Results: The results of this study showed that treatment with carbon tetrachloride significantly increased the level of MDA and decreased antioxidant capacity (P <0.001). Consumption of hop extract significantly ameliorated these factors in comparison to the untreated group (P <0.001). Conclusion: The results of this study showed that hop extract can protect the heart against oxidant compounds and free radicals produced by carbon tetrachloride metabolism.

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