MMP2 و MMP9: نگهبانان مسیرهای التهابی

عنوان انگليسی

MMP2 and MMP9: The inflammatory gatekeepers

خلاصه انگلیسی

Inflammatory processes are considered the essential hallmark of a broad range of pathological conditions. In the 21st century, lifestyle changes have laid the foundation for the emergence of a wide variety of acute as well as chronic diseases based on inflammation and inflammatory-related pathways. Matrix metalloproteinases (MMPs) are a key class of molecules primarily recruited for tissue repair and remodeling, embryonic development, and morphogenesis in the body via matrix degradation. However, alterations in this pathway can result in the emergence of diseases. In this narrative review, we summarized the recent significant findings of the available valid literature regarding the relationship between metalloproteinase 2 and 9 and inflammatory pathways and related diseases extracted from scientific databases including Scopus, ScienceDirect, and Pubmed. Recently, matrix metalloproteinases 2 and 9 have emerged as important regulatory molecules in inflammation-related pathophysiological processes such as oxidative stress. MMP9 has been found to be upregulated across an extensive range of cancers, while interestingly MMP2 is mostly found to be downregulated. MMP2 and MMP9 are also reported to be involved in the pathogenesis of autoimmune diseases, diabetes, as well as atherosclerosis. Many herbal extracts such as linalool and food supplementations including omega-3-fatty acid have been found to improve oxidative stress parameters by directly influencing the function of MMP2 and MMP9. Studying and understanding the exact mechanisms by which MMP2 and MMP9 exert their function can aid in the process of developing brand-new and novel therapeutic approaches. In this narrative review, we summarize the role of MMP2 and MMP9 in inflammation

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