استفاده از قدرت طبیعت: بابونه به عنوان یک گیاه امیدبخش در پزشکی

عنوان انگليسی

Harnessing nature’s power: Feverfew as a promising herb in medicine

خلاصه انگلیسی

Autoimmune diseases, Cancers, and diabetes have emerged as the tenacious diseases of the current era due to lifestyle changes. With drastic breakthroughs of the 20th and 21st centuries in the area of medicine, herbs and traditional approaches have mostly been replaced with synthetic therapeutics. However, the medicinal potential of long-used herbs should not be overlooked. Feverfew (Tanacetum parthenium), originally used for the treatment of migraine and inflammation for centuries, is a traditional herbal remedy with broad geographical distribution and is rich in a large number of natural active products such as sesquiterpene lactones including parthenolide as well as flavonoid glycosides and pinenes. In this narrative review, we summarized the recent significant findings of the available valid literature regarding the relationship between the use of Feverfew and a wide range of pathological as well as physiological conditions extracted from scientific databases including Scopus, ScienceDirect, and Pubmed. Additional experiments have demonstrated some beneficial effects of Feverfew in treating autoimmune conditions, asthma, allergies, fever, tinnitus, dizziness, nausea, infertility, menstruation problems, and diabetic-induced neuropathy. Feverfew can inhibit oxidative stress-mediated tissue damage caused by various toxic chemicals such as carbon tetrachloride by increasing superoxide dismutase, glutathione peroxidase, catalase activity, improving total antioxidant capacity, lowering malondialdehyde levels, regulating p53 pathway, and inhibition of STAT3/NF-kB and Nrf2/Keap1 pathways, inflammasome activation, as well as downregulation of lipopolysaccharide-mediated tumor necrosis factor-a (TNF-α), MCP-1, interleukin-6, interleukin-1B, prostaglandins, COX-2, and leukotrienes production. In addition, Feverfew displays anti-cancer properties by influencing cell proliferation rate as a result of its regulatory effects on nucleotide, lipid, and protein metabolism. The vast medicinal properties and safety of Feverfew necessitate further research to discover the exact mechanisms by which this herb displays its therapeutic effects.

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