رابطه بین چاقی و غلظت آمین اکسیداز پلاسمایی

عنوان انگليسی

the study on the relationship between obesity and plasma amine oxidase concentration

خلاصه انگلیسی

Soluble copper-containing amine oxidases (AOs) from mammals are dimeric proteins that react with a ping-pong mechanism consisting of enzyme reduction by primary amines and subsequent re-oxidation by molecular oxygen. AOs which oxidize biologically active and biogenic amines to producing amino aldehydes, ammonia and hydrogen peroxide catabolites are considered as biological regulators, especially in cell growth and differentiation. Furthermore their primary involvement in the inhibition or progression of cancer is probably due to balance between the actions of AOs and antioxidant enzymes like copper–zinc superoxide dismutase (Cu,ZnSOD) on the products of biogenic amine oxidation, H2O2, and ROS (Reactive Oxygen Species). Oxidation products may be involved in cataract formation, as shown by the direct proportionality between AO content and lens opacity. Increased levels of plasma AO have been reported in patients with Type 1 and Type 2 diabetes mellitus, congestive heart failure, various forms of liver disease. Also elevations in plasma AO level were reported during pregnancy and in malignant hypertension, atherosclerosis. However patients with cerebral bleeding show a decrease in plasma AO level, no change were reported in the case of cerebral thrombosis or embolism. In this presentation our aim was study the relationship between obesity and plasma amine oxidase concentration. The study carried out on people with different weights. People with BMI (Body Mass Index) less than 18.5, 18.5-25, 25-30 and more than 30 were considered as underweight, normal, overweight and obese respectively; BMI accounted by dividing weight (Kg) to square of height in meters. T-test on people respectively showed for normal, overweight and obese people in average as 471, 505 and 552 ng/ml. Data showed a statistically insignificant difference between average amounts in mentioned groups and probable lack of relationship between obesity and plasma amine oxidase concentration could be concluded.

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