نقش آمین اکسیداز در گیاهان و اثرات ضد سرطانی آن

عنوان انگليسی

Function of amine oxidases in plants and inhibitory effect of them on cancer

خلاصه انگلیسی

Abstract Amine oxidases (AOs) present a class of enzymes, which are divided into two main groups based on chemical nature of the attached cofactor, including the AOs containing flavin adenine dinucleotide, (FAD-AOs, EC 1.4.3.4) and copper-containing amine oxidases, (CuAOs, EC 1.4.3.6), which have a tightly bound copper ion in their molecule. FAD-AOS and CuAOS present in all kinds of organisms such as bacteria, yeasts, mushrooms, various plants, and animals and catalyse the oxidative deamination of mono- and polyamines (essential compounds for cell growth and proliferation). Therefore, amine oxidases and products deriving from amines oxidation are essential in physiological processes. In plants H2O2, deriving from amines oxidation, has been correlated with cell wall maturation and lignifications during development, cell wall strength induction during pathogen infection, cell death induction during hypersensitive response and expression of defence genes. Aldehydes driving from amines oxidation involved in secondary metabolite synthesis and abiotic stress tolerance. Because of the higher content of biogenic amines in tumour cells in comparison to normal cells, AOs could behave as anticancer agent via apoptosis induction by H2O2production.

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