اثر تروگزروتین بر اختلال یادگیری و حافظه فضائی ناشی از آمیلوئید بتای 42-1 در موش بزرگ آزمایشگاهی

عنوان انگليسی

Protective Effects of Troxerutin on β-Amyloid (1-42)-Induced Impairments of Spatial Learning and Memory in Rats

خلاصه انگلیسی

Alzheimer's disease (AD) is a neurodegenerative disorder with a progressive cognitive decline and memory loss characterized pathologically by the appearance of senile plaques and neurofibrillary tangles (NFTs). β-amyloid peptide protein (Aβ) is a potent neurotoxic peptide and a major constituent of the senile plaques that leads to neural dysfunction. In the present study we examined the protective effect of Troxerutin, a natural bioflavonoid, on β-amyloid (1-42)-Induced impairment of learning and memory. Male Wistar rats (300–350 g) were divided into six groups: sham, Aβ (1-42), Aβ (42-1) and Aβ (1-42) injection plus treatment with three different doses of Troxerutin (50, 150, 300 mg/kg) for eight consecutive days. Aβ was injected intracerebroventricularly (i.c.v.) into right lateral ventricle and eight days after i.c.v. injection Morris water maze task was performed to assess spatial learning and memory. Our results showed that Troxerutin at lower doses (50, 150 mg/kg) had not any significant effect on Aβ induced impairment of memory performance, but the dose of 300 mg/kg of Troxerutin effectively protected Aβ induced impairment of spatial learning and memory in Aβ (1-42) treated animals. The improving effects of Troxerutin may be partly due to its antioxidant, anti-inflammatory activities and modification in cholinergic system.

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