شیوع مننژیت بعد از عمل جراحی با عامل اسینتو باکتر بومانی مقاوم به کارباپنم در بیمارستان نمازی 1390 – 1388

عنوان انگليسی

Prevalence of Post Operative Carbapenem Resistant Acinrtobacter Baumannii Meningitis in Namazi Hospital (2009-2011)

خلاصه انگلیسی

Background & Objectives: Community-acquired Acinetobacter meningitis in adults is an extremely rare infection of the central nervous system (CNS). Currently, Acinetobacter is the second most common agent of nosocomial meningitis in some hospital. The excessive utilization of the antibiotics in the hospitals had lead to an increase of A.baumannii stems with extended resistance to antibiotics, including to the new generations of extended-spectrum of Betalactamine, Aminoglycoside and Fluoroquinolone. The Carbapenemes were, until recently, elective antibiotics for the treatment of the infections determined by the stems of A.baumannii multidrug–resistant. Carbapenems have become the drugs of choice against Acinetobacter infections in many centers but are slowly being compromised by the emergence of carbapenem-hydrolyzing –lactamases The aim of this study is to determine the rate of Carbapeneme Resistant Acinrtobacter baumannii (CRAB) in Community-acquired Acinetobacter meningitis in patients hospitalized in namazi hospital during 2009 to 2011. Methods: 67 isolates of Acinrtobacter Baumannii were collected from 542 (12.3%) CSF samples of hospitalized patients in Namazi Hospital. Resistancy of these isolates evaluated against Imipenem. Using API for identifying the isolates and E.test methods, for evaluating CRAB isolates. Results: In E.test methods, 41of 67(61%) A.baumannii were resistant, 6(.08%) were intermediate and 20 (29%) were sensitive to Imipenem. Conclusion: This study shows that the extensive spread of CRAB can happen through the environmental contamination, and proper strategies including strict contact precautions, massive environmental decontamination, and a closed-suctioning system can be effective for controlling CRAB outbreaks.

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