تعديل ديابت نوع 1 ناشی از دوزهای کوچک استرپتوزوتوسين در موش سوری توسط متادون

امیرشاهرخی, کیوان and دهپور, احمدرضا and حاجتی, جمشيد and ستوده, مسعود and قاضی خوانساری, محمود (1387) تعديل ديابت نوع 1 ناشی از دوزهای کوچک استرپتوزوتوسين در موش سوری توسط متادون. Toxicology and Applied Pharmacology ــ 232 (1). pp. 119-124. شاپا 0041-008X

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Official URL: http://www.sciencedirect.com/science/journal/00410...


Methadone ameliorates multiple-low-dose streptozotocin-induced type 1 diabetes in mice

English Abstract

Type 1 diabetes is an autoimmune disease characterized by inflammation of pancreatic islets and destruction of β cells by the immune system. Opioids have been shown to modulate a number of immune functions, including T helper 1 (Th1) and T helper 2 (Th2) cytokines. The immunosuppressive effect of long-term administration of opioids has been demonstrated both in animal models and humans. The aim of this study was to determine the effect of methadone, a μ-opioid receptor agonist, on type 1 diabetes. Administration of multiple low doses of streptozotocin (STZ) (MLDS) (40mg/kg intraperitoneally for 5 consecutive days) to mice resulted in autoimmune diabetes. Mice were treated with methadone (10mg/kg/day subcutaneously) for 24days. Blood glucose, insulin and pancreatic cytokine levels were measured. Chronic methadone treatment significantly reduced hyperglycemia and incidence of diabetes, and restored pancreatic insulin secretion in the MLDS model. The protective effect of methadone can be overcome by pretreatment with naltrexone, an opioid receptor antagonist. Also, methadone treatment decreased the proinflammatory Th1 cytokines [interleukin (IL)-1β, tumor necrosis factor-α and interferon-γ] and increased anti-inflammatory Th2 cytokines (IL-4 and IL-10). Histopathological observations indicated that STZ-mediated destruction of β cells was attenuated by methadone treatment. It seems that methadone as an opioid agonist may have a protective effect against destruction of β cells and insulitis in the MLDS model of type 1 diabetes

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :کیوان امیرشاهرخی
نویسنده مسئول :محمود قاضی خوانساری
Additional Information:Impact Factor:3.364 Abstracting and Indexing : 1- ISI , Science Citation Index Expanded , MEDLINE ,Science Citation Index , 2-BIOSIS , Chemical Abstracts ,Current Contents (Life Sciences,EMBASE ,Scopus 3-Chemical Hazards Index , Clinical Medicine), EMBiology International Pharmaceutical Abstracts , Medical Abstracts Newsletter , Research Alert , Safety Science Abstracts , Toxicology Abstracts
Uncontrolled Keywords:متادون ، ديابت نوع1 ، سايتوکاین ، استرپتوزوتوسين
کلیدواژه ها (انگلیسی):Methadone , Multiple-low-dose-streptozotocin Type 1 diabetes , Cytokines
Subjects:QV pharmacology
WK Endocrine System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
ID Code:588
Deposited By: Dr Kivan Amir Shahrikhi
Deposited On:08 Nov 1388 11:17
Last Modified:07 Jul 1393 06:09

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