تعديل ديابت نوع 1 ناشی از دوزهای کوچک استرپتوزوتوسين در موش سوری توسط متادون

امیرشاهرخی, کیوان ، دهپور, احمدرضا ، حاجتی, جمشيد ، ستوده, مسعود ، قاضی خوانساری, محمود (1387) تعديل ديابت نوع 1 ناشی از دوزهای کوچک استرپتوزوتوسين در موش سوری توسط متادون. Toxicology and Applied Pharmacology ــ 232 (1). ص.ص.119-124. شاپا 0041-008X

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آدرس اینترنتی رسمی : http://www.sciencedirect.com/science/journal/00410...

عنوان انگليسي

Methadone ameliorates multiple-low-dose streptozotocin-induced type 1 diabetes in mice

خلاصه انگلیسی

Type 1 diabetes is an autoimmune disease characterized by inflammation of pancreatic islets and destruction of β cells by the immune system. Opioids have been shown to modulate a number of immune functions, including T helper 1 (Th1) and T helper 2 (Th2) cytokines. The immunosuppressive effect of long-term administration of opioids has been demonstrated both in animal models and humans. The aim of this study was to determine the effect of methadone, a μ-opioid receptor agonist, on type 1 diabetes. Administration of multiple low doses of streptozotocin (STZ) (MLDS) (40mg/kg intraperitoneally for 5 consecutive days) to mice resulted in autoimmune diabetes. Mice were treated with methadone (10mg/kg/day subcutaneously) for 24days. Blood glucose, insulin and pancreatic cytokine levels were measured. Chronic methadone treatment significantly reduced hyperglycemia and incidence of diabetes, and restored pancreatic insulin secretion in the MLDS model. The protective effect of methadone can be overcome by pretreatment with naltrexone, an opioid receptor antagonist. Also, methadone treatment decreased the proinflammatory Th1 cytokines [interleukin (IL)-1β, tumor necrosis factor-α and interferon-γ] and increased anti-inflammatory Th2 cytokines (IL-4 and IL-10). Histopathological observations indicated that STZ-mediated destruction of β cells was attenuated by methadone treatment. It seems that methadone as an opioid agonist may have a protective effect against destruction of β cells and insulitis in the MLDS model of type 1 diabetes

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :کیوان امیرشاهرخی
نویسنده مسئول :محمود قاضی خوانساری
اطلاعات اضافی :Impact Factor:3.364 Abstracting and Indexing : 1- ISI , Science Citation Index Expanded , MEDLINE ,Science Citation Index , 2-BIOSIS , Chemical Abstracts ,Current Contents (Life Sciences,EMBASE ,Scopus 3-Chemical Hazards Index , Clinical Medicine), EMBiology International Pharmaceutical Abstracts , Medical Abstracts Newsletter , Research Alert , Safety Science Abstracts , Toxicology Abstracts
کلید واژه ها:متادون ، ديابت نوع1 ، سايتوکاین ، استرپتوزوتوسين
کلید واژه ها (انگلیسی):Methadone , Multiple-low-dose-streptozotocin Type 1 diabetes , Cytokines
موضوعات :QV فارماکولوژی
WK سیستم غدد
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش فارماکولوژی
کد شناسایی :588
ارائه شده توسط : دکتر کیوان امیرشاهرخی
ارائه شده در تاریخ :08 بهمن 1388 11:17
آخرین تغییر :07 مهر 1393 06:09

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