مصطفی لو, سارا ، عبدالهی, محمد (1392) آفت کش ها و بیماری های مزمن انسان: شواهد، مکانیسم و چشم انداز. Toxicology and Applied Pharmacology ــ 268 (2). ص.ص.157-177. شاپا 0041-008X
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آدرس اینترنتی رسمی : http://www.sciencedirect.com/science/article/pii/S...
عنوان انگليسی
Pesticides and Human Chronic Diseases; Evidences, Mechanisms, and Perspectives
خلاصه انگلیسی
Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders. There is also circumstantial evidence on the association of exposure to pesticides with some other chronic diseases like respiratory problems, particularly asthma and chronic obstructive pulmonary disease (COPD), cardiovascular disease such as atherosclerosis and coronary artery disease, chronic nephropathies, autoimmune diseases like systemic lupus erythematous and rheumatoid arthritis, chronic fatigue syndrome, and aging. The common feature of chronic disorders is a disturbance in cellular homeostasis, which can be induced via pesticides' primary action like perturbation of ion channels, enzymes, receptors, etc., or can as well be mediated via pathways other than the main mechanism. In this review, we present the highlighted evidence on the association of pesticide's exposure with the incidence of chronic diseases and introduce genetic damages, epigenetic modifications, endocrine disruption, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum stress and unfolded protein response (UPR), impairment of ubiquitin proteasome system, and defective autophagy as the effective mechanisms of action.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | سارا مصطفی لو |
نویسنده مسئول : | محمد عبدالهی |
ضریب تاثیر و نمایه مجلات: | Impact Factor: 3.630 Abstracting and Indexing: Science Citation Index , PubMed, MEDLINE , BIOSIS , Chemical Abstracts , International Pharmaceutical Abstracts , Medical Abstracts Newsletter , EMBASE , Research Alert , Safety Science Abstracts , Toxicology Abstracts , Current Contents (Life Sciences, Clinical Medicine) Chemical Hazards Index , Scopus , EMBiology |
کلیدواژه ها (فارسی): | آفت کش، بیماری های مزمن، سمیت ژنتیک، اپی ژنتیک |
کلیدواژه ها (انگلیسی): | Pesticides, chronic disease, genotoxicity, epigenetics |
موضوعات : | QV فارماکولوژی > QV 600 سم شناسی QV فارماکولوژی |
بخش های دانشگاهی : | دانشکده داروسازی > بخش سم شناسی |
کد شناسایی : | 6394 |
ارائه شده توسط : | دکتر سارا مصطفی لو |
ارائه شده در تاریخ : | 04 اسفند 1393 06:45 |
آخرین تغییر : | 04 اسفند 1393 06:45 |
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