title

RalA in biology and therapy of MPNST in correlation to cancer stem cells

رضایی مقدم, عادل and زهره, صنعت and رویا, دولاخه and پات راد, الهام and امانی, مجتبی and اسفندیاری, طوبی and فراستی, فریس (1394) RalA in biology and therapy of MPNST in correlation to cancer stem cells. در: 3rd Biennial Pediatric Neuro-Oncology Basic and Translational Research Conference, May 7 - 8, 2015, San Diego, California.

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Title

RalA in biology and therapy of MPNST in correlation to cancer stem cells

English Abstract

For the last 20 years, cellular biologists have been focusing on the role of Ras signaling pathway in neurofibromatosis 1(NF1) and its lethal derivation, malignant peripheral nerve sheath tumors (MPNST). While our team has worked on the influence of Ras pathway on responsiveness of MPNST cells to therapy, we introduced a novel cell signaling pathway down-stream of Ras, i.e. Ral pathway, as an important regulator of the biological features of MPNST with potentials for being targeted for treatment of this malignancy. We have also showed that RalA is overactivated in the cancer stem cell (CSC) fraction of MPNST tumors establishing this pathway to harbor potentials for targeting MPNST CSCs. In summary our preliminary data shed light on following facts:

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده :مجتبی امانی
نویسنده مسئول :فریس فراستی
Additional Information:accepted abstracts will be published in an online supplement in the journal Neuro-Oncology
Subjects:QU Biochemistry
QZ Pathology
WH Hemic and Lymphatic System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biophysics
ID Code:6622
Deposited By: MS Soghra Golmaghani
Deposited On:29 Jan 1394 06:03
Last Modified:29 Jan 1394 06:03

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