رفاهی, سهیلا ، پورعیسی, مسعود ، زیرک, محمدرضا ، حدادی, غلامحسن (1394) مدولاسیون ژن (TNF-α) در آسیب ریوی ناشی از اشعه با استفاده از اسید گلیسریزیک. journal of medical physics ــ 40 (2). ص.ص.95-101. شاپا 6203-0971
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آدرس اینترنتی رسمی : http://www.jmp.org.in
عنوان انگليسی
Modulation expression of tumor necrosis factor α (TNF-α) in the radiation-induced lung injury by glycyrrhizic acid
خلاصه انگلیسی
To evaluate the ability of glycyrrhizic acid (GLA) to reduce the tumor necrosis factor α (TNF-α), release on messenger ribonucleic acid (mRNA) and protein production in the lungs using GLA in response to irradiation were studied. The animals were divided into four groups: No treatment (NT group), GLA treatment only (GLA group), irradiation only (XRT group), and GLA treatment plus irradiation (GLA/XRT group). Rats were killed at different time points. Real-time reverse transcriptase polymerase chain reaction (RT-PCR) was used to evaluate the mRNA expression of TNF-α in the lungs (compared with non-irradiated lungs). An enzyme-linked immunosorbant assay (ELISA) assay was used to measure the TNF-α protein level. The TNF-α mRNA expression in the lungs of the XRT rats was clearly higher at all-time points compared to the NT rats. The TNF-α mRNA expression in the lungs of the GLA/XRT rats was lower at all-time points compared to the XRT rats. Release of the TNF-α on protein level in the lungs of the XRT rats increased at all-time points compared to the NT rats. In contrast to the XRT rats, the lungs of the GLA/XRT rats revealed a reduction on TNF-α protein level at 6 h after irradiation. This study has clearly showed the immediate down-regulation of the TNF-α mRNA and protein production in the lungs using GLA in response to irradiation.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | سهیلا رفاهی |
نویسنده : | مسعود پورعیسی |
نویسنده : | محمدرضا زیرک |
نویسنده مسئول : | غلامحسن حدادی |
ضریب تاثیر و نمایه مجلات: | Indexing in: Pubmed, SCOPUS, Google Scholar, Index Copernicus, Indian Science Abstracts, Excerpta Medica / EMBASE |
کلیدواژه ها (انگلیسی): | Glycyrrhizic acid ,radiation induced lung damage , tumor necrosis factor α |
موضوعات : | QY آسیب شناسی بالینی WF سیستم تنفسی WN پرتو شناسی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش فیزیک پزشکی |
کد شناسایی : | 6745 |
ارائه شده توسط : | دکتر سهیلا رفاهی |
ارائه شده در تاریخ : | 05 مرداد 1394 06:00 |
آخرین تغییر : | 24 اسفند 1399 09:38 |
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