title

نقش ترکیبات ارگانوفسفره در تغییرات متابولیسم کبدی گلوکز به صورت مقاومت به انسولین به واسطه استرس اکسیداتیو و التهاب

مصطفی لو, سارا (1390) نقش ترکیبات ارگانوفسفره در تغییرات متابولیسم کبدی گلوکز به صورت مقاومت به انسولین به واسطه استرس اکسیداتیو و التهاب. در: 11th International of the Iranian Society of Toxicology, Sept 13-15, 2011, mashad - Iran.

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Title

Biochemical evidence on the potential role of organophosphates in hepatic glucose metabolism toward insulin resistance through inflammatory signaling and free radical pathways

English Abstract

Several studies show that organophosphate pesticides exert several effects on glucose homeostasis. The current study investigates the influence of subchronic exposure to malathion (MT) on hepatic gluconeogenesis in relation to acetyl cholinesterase (AChE) inhibition, oxidative stress and inflammatory response in the rat. MT was administered by gavage at doses of 25, 50 and 100 mg/kg for 32 days. Fasting hyperglycemia was seen in line with an increased activity of hepatic phosphoenolpyruvate carboxykinase, glucose 6-phosphatase and tumor necrosis factor α. In addition to the impaired glucose tolerance and inhibition of AChE in a dose-dependent manner, there were significant increases in hepatic lipid peroxidation, carbonyl groups and 8-deoxyguanosine as the biomarkers of reactive oxygen species-mediated damage to lipid, protein and DNA, respectively. Altered quality of the liver in glucose production especially gluconeogenesis could be a compensatory mechanism against MT toxicity or even result in tissue damage. MT-induced insulin resistance in the liver occurs through oxidative and inflammatory signaling pathways

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده اول :سارا مصطفی لو
کلیدواژه ها (انگلیسی):Organophosphates, glucose metabolism, insulin resistance, oxidative stress, inflammation
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:7966
Deposited By: Dr Sara Mostafalou
Deposited On:02 Sep 1395 11:08
Last Modified:02 Sep 1395 11:08

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