سطح پروتئین HS-CRP دربیماران ایرانی با عوارض ریوی ناشی از گاز خردل و ارتباط آن با شدت بیماری راه هوائی

عطاران, داود and محمدزاده لاری, شهرزاد and خواجه دلوئی, محمد and آیت اللهی, حسین and توحیدی, محمد and اثنی عشری, امیر and قبادی مراللو, حسن and مظلومی, مریم and بلالی مد, مهدی (1388) سطح پروتئین HS-CRP دربیماران ایرانی با عوارض ریوی ناشی از گاز خردل و ارتباط آن با شدت بیماری راه هوائی. Human and Experimental Toxicology ــ 28 (12). pp. 745-739. شاپا 0960-3271

Text - Published Version

Official URL: http://het.sagepub.com/content/vol28/issue12


Highly sensitive C-reactive protein levels in Iranian patients with pulmonary complication of sulfur mustard poisoning and its correlation with severity of airway diseases

English Abstract

Background: Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due to SM poisoning. Methods: Fifty consecutive SM patients with stable COPD and a mean age 46.3 + 9.18 years were enrolled in this cross sectional study. Thirty healthymen were selected as controls. Lung function parameters were evaluated. Serum hs-CRP by immunoturbidometry assay was measured in both the patients and controls. Results: In the case group, the mean forced expiratory volume in one second (FEV1) was 2.14 + 0.76 L (58.98%+17.51% predicted). The mean serum hs-CRP was 9.4+6.78 SD and 3.9+1.92 SDmg/L in the cases and controls, respectively, with significant statistical differences (p < .001). There was negative correlation between the serum hs-CRP and FEV1 levels (p ¼ .01). The serum hs-CRP levels were also correlated with Global Initiative for ChronicObstructive Lung disease (GOLD) stages (r ¼ .45, p < .001). Conclusions:Our findings suggest that the serum hs-CRP level is increased in SM patients with COPD and may have a direct correlation with disease severity. It may then be used as a marker for the severity of COPD in patients with SM poisoning.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :داود عطاران
نویسنده مسئول :شهرزاد محمدزاده لاری
Additional Information:Impact factor:1.456 Indexing: Science Citation Index , Science Citation Index Expanded , MEDLINE /PubMed , Scopus , Academic Search Premier , Biological Abstracts , BIOSIS database , BIOSIS Previews , Chemical Abstracts Service (CAS), Chimica , Current Citations , Current Contents / Life Sciences , , Elsevier BIOBASE/Current Awareness in Biological Sciences , EMBASE/Excerpta Medica , Index Medicus , Index Veterinarius , Medical Documentation Service , Neurosciences Abstracts , Nutrition Abstracts & Review Series A: Human & Experimental
کلیدواژه ها (انگلیسی):chemical warfare agents, sulfur mustard gas, veterans, chronic obstructive pulmonary disease, highly sensitive C-reactive protein
Subjects:WF Respiratory System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:819
Deposited By: Dr Hassan Ghobadi
Deposited On:02 Dec 1388
Last Modified:05 Jan 1393 10:03

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