اثر هم افزایی چندین ماده ضد گلیکه (MB-92)برمهار گلیکه شدن پروتیئن، بد چین خوردن و اختلالات دیابتی در موش صحرایی دیابتی - آنروسکلروزی

مهدوی فرد, سیدسینا/ صفدر and بطحایی, سیده زهرا and نخجوانی, منوچهر and تقی خانی, محمد (1395) اثر هم افزایی چندین ماده ضد گلیکه (MB-92)برمهار گلیکه شدن پروتیئن، بد چین خوردن و اختلالات دیابتی در موش صحرایی دیابتی - آنروسکلروزی. European Journal of Medicinal Chemistry ــ 121 . pp. 892-902. شاپا 0223-5234

[img] Text - Published Version
محدود به Repository staff only


Official URL: http://www.sciencedirect.com/science/journal/02235...


The synergistic effect of antiglycating agents (MB-92) on inhibition of protein glycation, misfolding and diabetic complications in diabetic-atherosclerotic rat

English Abstract

Protein glycation due to hyperglycemia resulting in misfolding and aggregation, which is known as one of the most important reasons of diabetes complications. We previously showed the beneficial effects of some antiglycating agents in diabetic rats. Here, the effect of MB-92, a combination of some amino acids and crocetin (Crt, a saffron carotenoid), was studied in the prevention of diabetic complications in diabetic-atherosclerotic rats. In addition, the inhibitory effect of these treatments on glycation intermediates, aggregation and misfolding of proteins was investigated both in vivo and in vitro. Thus, the streptozotocin-induced diabetic rats that underwent an atherogenic diet were treated with Crt, N-acetylcyctein and MB-92. Then, glycated products and markers of oxidation and inflammation, in addition to other markers of diabetes complications were studied. The results of the in vivo study indicated that the mentioned treatments prevented the atheromatos formation, reduced the increased blood glucose; inhibited the formation of various glycation products, induced glyoxalase system (I and II), diminished oxidation and inflammatory markers, and improved lipid profile and atherosclerotic index in the diabetic-atherosclerotic rats; but MB-92 was the most effective treatment. In vitro results also confirmed that MB-92 was the most effective treatment to inhibit protein glycation and misfolding in comparison with the other treatments. In conclusion, MB-92 showed the greatest potential for inhibition of glycation and oxidation products, atheromatose plaque formation and inflammation in diabetic-atherosclerotic rats, and to control protein glycation, misfolding and aggregation in high glucose concentration; thus, it can be suggested as a new drug to prevent diabetic complications.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سیدسینا/ صفدر مهدوی فرد
نویسنده مسئول :سیده زهرا بطحایی
Additional Information:Impact Factor (2015) 3.902 Indexed in: ISI, pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts, BIOSIS, Elsevier BIOBASE, CNRS/Pascal, Current Contents/Life Sciences, EMBASE
کلیدواژه ها (انگلیسی):Combinatorial therapy, Glycated products, Misfolding, Aggregation, Diabetic complications, Atheromatose plaque, Crocetin, Amino acids, Streptozotocin
Subjects:QU Biochemistry
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
ID Code:8753
Deposited By: Dr Sina Mahdavifard
Deposited On:09 Mar 1396 05:55
Last Modified:26 Jan 1400 12:38

Repository Staff Only: item control page

Document Downloads

More statistics for this item...