بامداد, خیام and پورمحمد, پیروز and ذبیحی, اسلام and محمودزاده, یاور (1395) تاثیر عصاره متانولی بابونه گاوی بر سطح سرمی آریل استراز در موش صحرایی درمان شده با تتراکلرید کربن. در: The Third International And The Sixth National Conference Of Medical Herbs And Stable Agriculture, Dec 1 , 2016, Hamedan - Iran.
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Title
Effect of Tanacetum parthenium methanolic Extract (TPME) on serum arylesterase activity in rats treated with CCl4
English Abstract
Paraoxonase1 (PON1) is an enzyme that associated with high density lipoprotein (HDL), and demonstrating esterase and lactonase activity. The PON1 has a role in a variety of inflammatory conditions, metabolism of oxidized lipids and detoxifying of organophosphorus insecticide substrate. The aim of this study was to investigate the effects of Tanacetum parthenium methanolic extract (TPME) on arylesterase activities in CCl4 injected rats. Experiments were conducted in five groups of normal, CCl4 and different dose of TPME (TPME40, 80 and120mg/kg) rats. Two weeks after receiving the different dosages of TPME, CCl4 were administered intraperitoneally on the 16th day.after 48h blood samples were taken from animals and HDL level, arylesterase activity of PON1 enzyme and standardized activities of arylesterase (ARE/HDL) were measured in rats. Relative changes in serum HDL and arylesterase activities were compared between the groups. Administration of TPME significantly increased serum arylesterase activities and HDL level in CCl4 treated groups compared to untreated ones. These essential effects may be due to the presence of natural antioxidants such as phenolic compounds in the TPME. Methanolic extract of T.parthenium may be useful in decreasing the symptoms of diseases resulting from the low activity of ARE.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| زبان سند : | انگلیسی |
| نویسنده اول : | خیام بامداد |
| نویسنده : | پیروز پورمحمد |
| نویسنده : | اسلام ذبیحی |
| نویسنده مسئول : | یاور محمودزاده |
| کلیدواژه ها (انگلیسی): | Arylesterase, CC14, Oxidative Stress, Paraoxonase, Tanacetum Parthenium |
| Subjects: | QT physiology |
| Divisions: | Faculty of Medicine > Department of Basic Sciences > Department of physiology |
| ID Code: | 8939 |
| Deposited By: | آقای اسلام ذبیحی |
| Deposited On: | 11 Apr 1396 09:16 |
| Last Modified: | 23 Mar 1397 11:54 |
Available Versions of this Item
- تاثیر عصاره متانولی بابونه گاوی بر سطح سرمی آریل استراز در موش صحرایی درمان شده با تتراکلرید کربن. (deposited 11 Apr 1396 09:16) [Currently Displayed]
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