title

اثر رژیم غذایی پرچرب بر پاسخ دهی تراشه نسبت به متاکولین و ایندکس های مقاومت انسولینی در رت های نر و ماده حساس شده با اوآلبومین

قبادی مراللو, حسن ، علیپور, محمد رضا ، کیهان منش, رعنا ، بسکابادی, محمد حسین ، اصلانی, محمدرضا (1397) اثر رژیم غذایی پرچرب بر پاسخ دهی تراشه نسبت به متاکولین و ایندکس های مقاومت انسولینی در رت های نر و ماده حساس شده با اوآلبومین. Iranian Journal of Allergy, Asthma and Immunology ــ 18 (1). ص.ص.48-61. شاپا 1735-1502

متن کامل

[img]
پیش نمایش
متنی - نسخه چاپ شده
569kB

آدرس اینترنتی رسمی : http://ijaai.tums.ac.ir/index.php/ijaai/article/vi...


عنوان انگليسی

Effect of High-fat Diet on Tracheal Responsiveness to Methacholine and Insulin Resistance Index in Ovalbumin-sensitized Male and Female Rats

خلاصه انگلیسی

Epidemiological and clinical studies have demonstrated a close association between obesity and asthma. The current study investigated the effect of high-fat diet on tracheal responsiveness to methacholine and insulin resistance in ovalbumin (OVA) sensitized male and female rats. The rats were divided into eight groups (n=6 per group): female with the normal diet (F+ND), male with the normal diet (M+ND), female OVA-sensitized with the normal diet (F+SND), male OVA-sensitized with the normal diet (M+SND), female with high-fat diet (F+HFD), male with high-fat diet (M+HFD), female OVA-sensitized with high-fat diet (F+SHFD), and male OVA-sensitized with high-fat diet (M+SHFD). All rats were fed for 8 weeks with high-fat diet or standard pelts, and for another 4 weeks, they were sensitized with OVA or saline. At the end of the study, the tracheal responsiveness to methacholine, serum insulin, and blood glucose levels was measured. Also, insulin resistance indexes were determined. OVA-sensitization and diet-induced obesity caused the curve of methacholine concentration response to shifting to the left. In addition, results indicated that the EC50 (the effective concentration of methacholine generating 50% of peak response) in F+SHFD rats was statistically lower than M+SHFD group (p<0.05). Moreover, insulin resistance was higher in the F+SHFD than the M+SHFD group (p<0.001). These results suggest that insulin resistance and metabolic syndrome may be involved in the pathogenesis of obesity associated with OVA-sensitized rats condition, especially in female animals

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :حسن قبادی مراللو
نویسنده :محمد رضا علیپور
نویسنده :رعنا کیهان منش
نویسنده :محمد حسین بسکابادی
نویسنده مسئول :محمدرضا اصلانی
ضریب تاثیر و نمایه مجلات:IF:1.049 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):Airway hyper-responsiveness; Asthma; Insulin-resistance; Obesity; Wistar rats
موضوعات :QT فیزیولوژی
WF سیستم تنفسی
بخش های دانشگاهی :دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
دانشكده پزشكي > گروه علوم پایه > بخش فیزیولوژی
کد شناسایی :11840
ارائه شده توسط : دکتر محمد رضا اصلانی
ارائه شده در تاریخ :01 خرداد 1398 15:46
آخرین تغییر :26 شهریور 1402 12:54

فقط پرسنل کتابخانه صفحه کنترل اسناد

Document Downloads

More statistics for this item...