حمیدی, نسرین ، نوزاد, عبدالله ، شیخکانلوی میلان, حمید ، سالاری, علی اکبر ، امانی, محمد (1398) اثر سفتریاکسون بر پاسخ زوج-تحریک و تقویت طولانی مدت نورونهای شکنج دندانه دار هیپوکامپ در موش های مدل آلزایمری. Life sciences ــ 238 (116969). ص.ص.1-9. شاپا 0024-3205
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آدرس اینترنتی رسمی : https://www.journals.elsevier.com/life-sciences
عنوان انگليسی
Effect of ceftriaxone on paired-pulse response and long-term potentiation of hippocampal dentate gyrus neurons in rats with Alzheimer-like disease
خلاصه انگلیسی
Glutamatergic dysfunction is posed as a main stage in neurodegenerative disorders such as Alzheimer's disease (AD). Glutamate-mediated excitotoxicity contributes to cognitive dysfunction and cell death in AD. Ceftriaxone (CFT), a well-known upregulator of GLT-1, selectively induces the expression of glutamate transporter-1 (GLT-1) in different brain regions and therefore can be posed as a potential candidate for elimination of glutamate-induced excitotoxicity which is an early prominent event in AD brains. This study was designed to investigate the electrophysiological and behavioral effects of the β-lactam antibiotic ceftriaxone in okadaic acid (OKA)-induced model of AD. MATERIALS AND METHODS: Male Wistar rats divided into four control, ceftriaxone (CFT), OKA, and OKA plus ceftriaxone (OKA + CFT) groups. OKA was injected intracerebroventricularly (i.c.v., 200 ng/5 μl) into lateral ventricles and after two weeks the evoked field potential recorded from hippocampal perforant path-DG synapses in order to evaluate the effect of ceftriaxone treatment (200 mg/kg/day, i.p.) on long-term potentiation (LTP) and paired-pulse responses. KEY FINDINGS: Results of this study revealed that ceftriaxone treatment significantly ameliorates the OKA-induced attenuation of field excitatory post-synaptic potential (fEPSP) slope and population spike (PS) amplitude following high-frequency stimulation and paired-pulse paradigm indicating its beneficial effects on both short-term and long-term plasticity in these neurons. Ceftriaxone also has an improving effect on OKA-induced impairment in short- and long-term memories evaluated by alternation behavior and passive avoidance tasks in rats. SIGNIFICANCE: Therefore, this study suggests that GLT-1 might be a promising therapeutic target for treatment of neurodegenerative disorders such as AD in the future.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | نسرین حمیدی |
نویسنده : | عبدالله نوزاد |
نویسنده : | حمید شیخکانلوی میلان |
نویسنده : | علی اکبر سالاری |
نویسنده مسئول : | محمد امانی |
ضریب تاثیر و نمایه مجلات: | IF: 5.037 Indexed in: ISI, PubMed/Medline, Scopus, Embase |
کلیدواژه ها (انگلیسی): | lzheimer's disease; Ceftriaxone; Dentate gyrus; Okadaic acid; Synaptic plasticity |
موضوعات : | QT فیزیولوژی WL سیستم عصبی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش فیزیولوژی |
کد شناسایی : | 12396 |
ارائه شده توسط : | دکتر حمید شیخکانلوی میلان |
ارائه شده در تاریخ : | 20 آبان 1398 10:56 |
آخرین تغییر : | 01 مرداد 1402 09:25 |
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