اثر شل کنندگی تیموس ولگاریس بر زنجیره تراشه خوکچه هندی و مکانیسم های احتمالی آن

عنوان انگليسی

RELAXANT EFFECT OF TYMUS VOLGARIS ON GUINEA PIG TRACEAL CHAINS AND ITS POSSIBLE MECHANISM(S)

خلاصه انگلیسی

Therapeutic effect of Tymus volgaris on respiratory diseases is indicated in Iranian ancient Medical books. In the present study, the relaxant effects of macerated and aqueous extracts of Tymus volgaris on tracheal chains of guinea pigs were examined. The relaxant effects of 4 cumulative concentrations of macerated and aqueous extracts (0.25, 0.5, 0.75, and 1.0 W/V) in comparison with saline as negative control and 4 cumulative concentrations of theophylline (0.25, 0.5, 0.75, and 1.0 mM) were examined by their relaxant effects on pre-contracted tracheal chains of guinea pig by 60 mM KCl (group 1) and 10 µM methacholine in two different conditions including: non-incubated tissues (group 2) and incubated tissues with 1 µM propranolol and 1 µM chlorpheniramine (group 3), (for group 1 and 3, n=5 and for group 2, n=7). In groups 1 and 2 experiments both and theophylline showed concentration dependent relaxant effects compared to that of saline (p<0.05 to p<0.001 for different concentrations except the first concentration). The effects of last concentration of both extracts in group 2, two higher concentrations of macerated and 0.75 W/V aqueous extract were significantly lower than those theophylline (p<0.01 to p<0.001). However, in group 3 experiments extracts of Tymus volgaris did not show any significant relaxant effect. The effect of last concentration of aqueous extract in group 1 was only significantly different than that of macerated extract. There were significant correlations between the relaxant effects and concentrations for both extracts and theophylline in all experimental groups. These results showed a potent relaxant effect of Tymus volgaris on tracheal chains of guinea pigs that was comparable to that of theophylline at concentrations used.

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