حلیمی, منیره ، پورلک, طلا ، کلارستاقی, حسین ، برقی, بیتا ، مقیمیان, مریم ، نیازکار, حمیدرضا ، شکوهی, مجید (1400) تأثیر عصاره میخک بر عوامل باروری مردانه و استرس اکسیداتیو پس از پیچ خوردگی/دتورشن در موش های صحرایی نر بالغ با استفاده از روش تلقیح داخل رحمی. International Journal of Women's Health and Reproduction Sciences ــ 9 (4). ص.ص.1-6. شاپا 2330-4456
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آدرس اینترنتی رسمی : http://ppj.phypha.ir/article-1-1257-en.html
عنوان انگليسی
Effects of Syzygium Aromaticum (Clove) Extract on Male Fertility Factors and Oxidative Stress After Torsion/Detorsion in Adult Male Rats Using Intrauterine Insemination Method
خلاصه انگلیسی
Objectives: The current study was conducted on adult male models to assess the impact of the Syzygium aromaticum (clove) extract on male fertility factors and oxidative stress after torsion/detorsion using the intrauterine insemination (IUI) method. Materials and Methods: This experimental study was performed on 56 adult male Wistar rats including 28 males and 28 females. The male subjects were randomly assigned to four groups of sham (G1), 4 hours of testicular torsion following a surgical torsion/detorsion (TD/G2), TD treated with the clove extract (4 mg/kg, orally/G3) 30 minutes before detorsion, and healthy subjects treated with the clove extract (4 mg/kg/G4). The levels of blood testosterone and some oxidative stress indices were investigated in the testis tissue. In addition, some sperm parameters were evaluated, including the concentration, motility, and morphology of the sperm. Finally, the fertilization potential of adult female rats was assessed through the IUI method. Results: The histological evaluation revealed considerable adverse changes in the G2 in comparison with the sham group. The serum levels of testosterone, and glutathione peroxidase, and superoxide dismutase meaningfully reduced in the testis of rats in the G2. In addition, the malondialdehyde level was significantly higher during the ischemia although all the mentioned changes improved in the treated groups. Nonetheless, the sperm quality and fertility power considerably reduced in the G2 compared to the sham group. Conclusions: The results of the current experimental study demonstrated that the testicular torsion/detorsion has an adverse impact on the testis function and decreases the fertilization potential, and finally, treatment with the clove extract can improve these adverse changes.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | منیره حلیمی |
نویسنده : | طلا پورلک |
نویسنده : | حسین کلارستاقی |
نویسنده : | بیتا برقی |
نویسنده : | مریم مقیمیان |
نویسنده : | حمیدرضا نیازکار |
نویسنده مسئول : | مجید شکوهی |
ضریب تاثیر و نمایه مجلات: | Indexed in: Scopus, ESCI , Embase |
کلیدواژه ها (فارسی): | استرس اکسیداتیو، میخک، بیضه، باروری، تلقیح داخل رحمی |
کلیدواژه ها (انگلیسی): | Keywords: Oxidative stress, Clove, Testis, Fertility, Intrauterine insemination |
موضوعات : | QS آناتومی انسان QT فیزیولوژی QY آسیب شناسی بالینی WK سیستم غدد |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش علوم تشريح |
کد شناسایی : | 14981 |
ارائه شده توسط : | دکتر حسین کلارستاقی |
ارائه شده در تاریخ : | 29 مرداد 1401 10:29 |
آخرین تغییر : | 29 مرداد 1401 10:29 |
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