اثرات مفید محیط غنی شده بر رفتار، عملکردهای شناختی و سطح BDNF هیپوکامپ به دنبال کاهش سروتونین در اوایل زندگی در موش های صحرایی نر

عنوان انگليسی

Beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal BDNF level following postnatal serotonin depletion in male rats.

خلاصه انگلیسی

The neurotransmitter serotonin (5-HT) is one of the most important modulators of neural circuitry and has a critical role in neural development and functions. Previous studies indicated that changes in serotonergic system signaling in early life critically impact mental health, behavior, the morphology of hippocampal neurons, and cognitive functions across the lifespan. The enriched environment (EE) has indicated beneficial effects on behavior and cognitive functions in the developmental period of life, but its impacts on cognitive impairments and behavioral changes following postnatal serotonin depletion are unknown. Therefore, the present study aimed to evaluate the influences of the EE housing (Postnatal day: PND21-60) following postnatal serotonin depletion (by para-chlorophenylalanine: PCPA, 100mg/kg, sc, in PND 10-20) on anxiety-related behaviors, cognitive functions, and brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampus of male rats. Memory and behavioral parameters were examined in early adulthood and after that, the hippocampi of rats were removed to determine the BDNF mRNA expression by PCR (PND60-70). The findings of the present work indicated that adolescent EE exposure alleviated memory impairment, decreased BDNF levels, and anxiety disorders induced by experimental depletion of serotonin. Overall, these results indicate that serotonergic system dysregulation during the developmental periods can be alleviated by adolescent EE exposure.

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