بررسی فراوانی ژن های qur مقاومت به سیپروفلوکساسین در ایزوله های E.coli جدا شده از نمونه بالینی بیمارستان های ایلام و میلاد تهران

عنوان انگليسی

Prevalence of Non-qnr Genes in Escherichia coli Resistant to Ciprofloxacin Isolated from Urinary Tract Infection in Ilam and Tehran (Milad) Hospitals

خلاصه انگلیسی

Background & Objectives: Extensive use of quinolones has been associated with raising level of resistance. In the current study, we focused on assessing the prevalence of Escherichia coli resistance to quinolones and frequency of non-qnr genes. Methods: One hundred and fifty Escherichia coli isolates were identified during Mar.2007 to Apr.2012 in Ilam hospitals and Milad (Tehran) hospital.PCR was performed for detection of ParE, ParC, gyrB, acc(Ib)cr genes. Results: Of 150 isolates, sixty nine isolates (46%) were resistance to ciprofloxacin. Frequency of ParE, ParC, gyrB, acc(Ib)cr, were 76.8%(53 isolates), 78.54%(26 isolates), 71.01%(49 isolates) and 95.65%(66 isolates) respectively. Among non-qnr genes resistance to ciprofloxacin aac(Ib)cr had high freqency (95.65%). 21.3 % (32 isolates) had all four genes together. Three gense (ParC, gyrB, acc(Ib)cr) were seen in 31.8%(22 isolates ). Two isolates (2.8%) had one gene (acc(Ib)cr) only. Conclusion: Our study showed high frequency of non-qnr quinolone resistance gense in Ilam and Tehran (Milad) hospitals.

Document Downloads