قبادی مراللو, حسن ، محمدزاده لاری, شهرزاد ، امانی, فیروز ، حبیب زاده, شهرام ، کریمی, امیرحسین ، پورفرضی, فرهاد (1393) تاثیر درمان بر سطح سرمی پروکلسیتونین در بیماران با سل فعال ریوی. Journal of Cardio-Thoracic Medicine ــ 2 (4). ص.ص.238-242. شاپا 2345-2447
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آدرس اینترنتی رسمی : http://jctm.mums.ac.ir/article_3494_394.html
عنوان انگليسی
The Impact of Treatment on Serum Level of Procalcitonin in Patients with Active Pulmonary Tuberculosis
خلاصه انگلیسی
Introduction: About one third of the world's population is infected with tuberculosis (TB) and each year, about 1.5 to 2 million people die from TB. Procalcitonin (PCT) is an inflammatory marker that its level has variable results. There are some discussions in the utilization of PCT as a diagnostic marker in active pulmonary TB. The aim of this study was to compare serum PCT before and after treatment in patients with pulmonary TB. Materials and Methods: This conducted on patients with pulmonary TB. Data were collected using a check list. The serum level of PCT was measured by ELISA test at the beginning and after six months of treatment. All data were analyzed using SPSS 16. Results: Forty-two patients with active pulmonary TB entered in this study. The mean age of the patients was 45.48 ± 12.54 years and 54.8% of them were male. Most of the patients (59.5 %) were rural inhabitants. There was a family history of TB in 26% of patients. The most common symptom (45.2%) was cough. Mean PCT prior to treatment was 1.25 ± 0.98 ng/ml. and 81% of the patients had PCT higher than 0.5 to 5. After treatment PCT level reduced significantly (P<0.001). The mean erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) before treatment were 45.88 ± 21.87 and 7.16 ± 3.98 respectively that were reduced significantly after treatment (P<0.001). Neutrophil counts before treatment was 6221 ± 3161 Cells per ml. and decreased statistically significant after treatment (P=0.01). Conclusion: Our results showed that the PCT levels in pulmonary TB were high in active disease and reduced after treatment. PCT level may be used for follow-up as a discriminative marker between active and cured pulmonary TB and predict treatment response, although the PCT assay cannot be substituted for microbiological and pathological data.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | حسن قبادی مراللو |
نویسنده : | شهرزاد محمدزاده لاری |
نویسنده : | فیروز امانی |
نویسنده مسئول : | شهرام حبیب زاده |
نویسنده : | امیرحسین کریمی |
نویسنده : | فرهاد پورفرضی |
ضریب تاثیر و نمایه مجلات: | Indexed in : Directory of Open Access Journals (DOAJ) , Index copernicus , Islamic World Science Citation Database (ISC) , Index Medicus , Magiran |
کلیدواژه ها (انگلیسی): | Inflammatory Marker , Procalcitonin . Pulmonary Tuberculosis |
موضوعات : | WC بیماریهای واگیر WF سیستم تنفسی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه داخلی ، قلب ، عفونی |
کد شناسایی : | 6074 |
ارائه شده توسط : | دکتر حسن قبادی |
ارائه شده در تاریخ : | 26 آبان 1393 09:31 |
آخرین تغییر : | 20 اردبهشت 1399 15:39 |
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