اثر محافظتی تروگزروتین بر تقویت بلند مدت نورون های شکنج دندانه دار در مدل آلزایمری بتا آمیلوئید

عنوان انگليسی

Effect of Troxerutin on long-term potentiation (LTP) of dentate gyrus neurons in a β-amyloid model of Alzheimer’s disease

خلاصه انگلیسی

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that impairs ability of learning and memory. β-Amyloid (Aβ) is a primary factor leading to this neurodegenerative disorder. The present study investigated the protective effect of Troxerutin, a derivative of natural bioflavonoid, on long-term potentiation (LTP) in dentate gyrus neurons of hippocampus in a β-amyloid model of Alzheimer’s disease. Male Wistar rats weighing were divided into three groups, sham-operated, Aβ1-42 injected and Aβ1-42 plus Troxerutin-treated animals. Troxerutin (300 mg/kg) was administered by gavage for 14 days after intracerebroventricular injection of Aβ1-42. Troxerutin treatment enhanced LTP in dentate gyrus neurons blocked by Aβ1-42. These findings suggest that Troxerutin could have a beneficial effect on learning and memory impairment induced by Aβ (1– 42) in Alzheimer’s disease.

Document Downloads