ایجاد مدل اضافه باری ثانویه آهن در قلب موش صحرایی نژاد اسپراگو

منافی, فریده and علی پناه مقدم, رضا and نعمتی, علی and مهری پیرایواتلو, آرش and ملک زاده, ودود (1395) ایجاد مدل اضافه باری ثانویه آهن در قلب موش صحرایی نژاد اسپراگو. در: The 1 st National congress on Animal models in experimental medical researches, Apr 14, 2016, Shiraz - Iran.


Official URL: http://animalmodelcong.sums.ac.ir/fa/


establishment secondary heart iron overload model in sprague rat

English Abstract

Objective: Secondary iron overload is one of complication of Periodic blood transfusion in patients with hematologic diseases. Iron overload can result in iron deposition in heart tissue, which decreases cardia function, ultimately lead to death due to dilated cardiomyopathy and cardiac failure. Therefore, in this project, we established Rat model of secondary iron overload. This study can serve as an animal model for more investigations in the treatment of patients with cardiac iron overload. Methods: 1n this work, we developed an experimental secondary iron overload model in rats by using iron ucrose injection. Sixteen animals were divided into two equal groups and treated with dose of iron sucrose : 75mg/k.g body weight per day via injection for 12 consecutive days and Heart histopathology and iron overload was evaluated. Result: Our histoparhology findings in heart of all iron treated animals showed the deposition of iron to the umulated iron dose. Conclusion: Developing an appropriate animal's model best suited for the iron overload in-vivo study undertaken can reveal the pathogenesis of iron overload in heart. Hence, our data provides in-vivo evidence of iron overload may be useful for iron sucrose therapy, for iron deficiency anemia as weU as for the prevention and diagnosis of iron sucrose-induced iron overload in pediatric patients. Keyword: Iron overload, heart, animal model

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده :فریده منافی
نویسنده :رضا علی پناه مقدم
نویسنده :علی نعمتی
نویسنده :آرش مهری پیرایواتلو
نویسنده :ودود ملک زاده
کلیدواژه ها (انگلیسی):iron overload, heart, animal model
Subjects:QU Biochemistry
WG Cardiovascular System
WH Hemic and Lymphatic System
ID Code:8439
Deposited By: ودود ملک زاده
Deposited On:07 Nov 1395 08:39
Last Modified:07 Nov 1395 08:39

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