ارتباط بین هایپرهموسیستئینمی و استرس اکسیداتیو با شدت ضایعات اترواسکلروزیس

عنوان انگليسی

RELATIONSHIP BETWEEN HYPERHOMOCYSTEINEMIA, OXIDATIVE STRESS AND SEVERITY OF ATHEROSCLEROSIS LESIONS

خلاصه انگلیسی

OBJECTIVE: The aim of this study to evaluate correlation between hyperhomocysteinemia and oxidative stress with severity of atherosclerosis lesions. MATERIALS & METHODS: The patients (52 males and 36 females) were selected from individuals with angiographically defined CAD admitted to the Shahid Madani Hospital. Control groups were selected from sex and age matched apparently healthy individuals (15 males and 24 females). Serum homocysteine levels were measured by ELISA method (Awareness stat fax-2100 model). Total antioxidant capacity of samples was determined by autoanalyzer (COBAS MIRA plus model) using Randox kits. The correlation between the measured parameters and extension of atherosclerotic lesions were calculated using statistical analysis in the both groups. RESULTS: The mean levels of homocysteine in patients and control groups were 20.3810.22 µmol/l and 18.569.47 µmol/l respectively and the differences were not significant (P>0.05). In the patient group the mean level of antioxidant capacity was 1.340.12 mmol/l, whereas that of control was 1.390.12 mmol/l (P>0.05). Using statistical analysis no correlation was noticed between extension of atherosclerosis lesions, low total antioxidant capacity and high serum total homocysteine. CONCLUSION: In this study no significant differences between levels of homocysteine and total antioxidant in patients and control groups and no marked relationship between studied parameters suggest, that hyperhomocysteinemia has no important role in progress of atherosclerosis lesions.

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